Protective effect of starch-stabilized selenium nanoparticles against melamine-induced hepato-renal toxicity in male albino rats

Ahmed, Zainab Sabry Othman; Galal, Mona K.; Drweesh, Elsayed A.; Abou‐El‐Sherbini, Khaled S.; Elzahany, Eman A.M.; Elnagar, Mohamed M.; Yasin, Noha A. E.

doi:10.1016/j.ijbiomac.2021.09.156

Cited by 19 publications

(10 citation statements)

References 82 publications

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“…In addition, biogenic SeNPs synthesized using Moringa oleifera leaf extract antagonized renal apoptosis in melamine-exposed rats via down-regulation of the mRNA expressions of Bax, caspase-3, Bcl2, Fas, and FasL [ 34 ]. Similar anti-apoptotic effect was reported by another study using starch-stabilized Se-NPs [ 75 ]. This activity may endorse for scavenging of free radicals efficiently and impeding the apoptotic mitochondrial pathways.…”

Section: Discussionsupporting

confidence: 89%

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

ALRashdi,

Mohamed,

Mohamed

et al. 2023

Bioscience Reports

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Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with selenium nanoparticles (Tur-SeNPs) against CDDP-mediated renal impairment in mice and the mechanisms underlying this effect. Mice were orally treated with Tur extract (200 mg/kg) or Tur-SeNPs (0.5 mg/kg) for 7 days after administration of a single dose of CDDP (5 mg/kg, i.p.). N-acetyl cysteine NAC (100 mg/kg) was used as a standard antioxidant compound. The results revealed that Tur-SeNPs counteracted CDDP-mediated serious renal effects in treated mice. Compared with the controls, Tur or Tur-SeNPs therapy remarkably decreased the kidney index along with the serum levels of urea, creatinine, Kim-1, and NGAL of the CDDP-injected mice. Furthermore, Tur-SeNPs ameliorated the renal oxidant status of CDDP group demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Tur-SeNPs treatment also restored the renal histological features attained by CDDP challenge and hindered renal apoptosis through decreasing the Bax levels and increasing Bcl-2 levels. Altogether, these outcomes suggest that the administration of Tur conjugated with SeNPs is effective neoadjuvant chemotherapy to guard against the renal adverse effects that are associated with CDDP therapy.

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Section: Discussionsupporting

confidence: 89%

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

ALRashdi,

Mohamed,

Mohamed

et al. 2023

Bioscience Reports

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“…This is in accordance with a past report in which the authors reasoned that apoptosis assumes a fundamental part in PS-NP harmfulness (Jung et al 2020 ). One of the vital components in renal apoptosis is caspase-3 (Jeruc et al 2006 ; Ahmed et al 2021 ). At the point when the sign advancing cell development vanishes, Cytc overexpression causes apoptosis (Rashad et al 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Screening for polystyrene nanoparticle toxicity on kidneys of adult male albino rats using histopathological, biochemical, and molecular examination results

et al. 2022

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Polystyrene Nanoparticles (PS-NPs) used for packaging foam, disposable cups, and food containers. Therefore, this study aimed to evaluate PS- NPs toxic effects on kidney of adult male albino rats. A total of 30 rats divided into three groups (n = 10): group I negative control group; group II orally administered 3% PS-NPs (3 mg/kg body weight/day) and group III orally administered 3% PS-NPs (10 mg/kg body weight/day) for 35 days. Blood and kidney samples collected and processed for biochemical, histopathological, and immunohistochemical examinations. Results showed that low and high doses PS-NPs had significantly increased serum blood urea nitrogen (BUN), creatinine, malondialdehyde, significantly further reduced glutathione, downregulation of nuclear factor erythroid 2–related factor 2 and glutathione peroxidase, upregulation of caspase-3 and Cytochrome-c. Histopathological examination revealed several alterations. Low dose of PS-NPs exhibited dilated glomerular capillaries, hypotrophy of some renal corpuscles significantly decreases their diameter to 62 μm. Some proximal convoluted tubules and distal convoluted tubules showed loss of cellular architecture with pyknotic nuclei. Hyalinization and vacuolation in renal medulla. In high dose PS-NPs, alterations increased in severity. A significant increase in percentage area of cyclooxygenase-2 in low and high-doses. In conclusion, PS-NPs are a nephrotoxic causing renal dysfunction.

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“…Likewise, starch-based SeNPs were evaluated against melamine-induced hepatorenal toxicity in albino rats. Interestingly, administration of starch-based SeNPs resulted in remarkable protection in rats treated with melamine through the quenching of oxidative stress and increase in antioxidant parameters [ 124 ]. Moreover, SeNPs against APAP-induced hepatic damage possessed significant capability to restore the cellular structure and avoided further damage, thereby presenting a novel strategy for employing SeNPs as a hepatoprotective agent in the field of medicine [ 125 ].…”

Section: Nanoparticles and Their Interaction With Liver And Kidney Cellsmentioning

confidence: 99%

Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives

et al. 2022

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Liver and kidney diseases are the most frequently encountered problems around the globe. Damage to the liver and kidney may occur as a result of exposure to various drugs, chemicals, toxins, and pathogens, leading to severe disease conditions such as cirrhosis, fibrosis, hepatitis, acute kidney injury, and liver and renal failure. In this regard, the use of nanoparticles (NPs) such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc oxide nanoparticles (ZnONPs) has emerged as a rapidly developing field of study in terms of safe delivery of various medications to target organs with minimal side effects. Due to their physical characteristics, NPs have inherent pharmacological effects, and an accidental buildup can have a significant impact on the structure and function of the liver and kidney. By suppressing the expression of the proinflammatory cytokines iNOS and COX-2, NPs are known to possess anti-inflammatory effects. Additionally, NPs have demonstrated their ability to operate as an antioxidant, squelching the generation of ROS caused by substances that cause oxidative stress. Finally, because of their pro-oxidant properties, they are also known to increase the level of ROS, which causes malignant liver and kidney cells to undergo apoptosis. As a result, NPs can be regarded as a double-edged sword whose inherent therapeutic benefits can be refined as we work to comprehend them in terms of their toxicity.

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Protective effect of starch-stabilized selenium nanoparticles against melamine-induced hepato-renal toxicity in male albino rats

Cited by 19 publications

References 82 publications

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Screening for polystyrene nanoparticle toxicity on kidneys of adult male albino rats using histopathological, biochemical, and molecular examination results

Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives

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