Protective Effect of the Hydroxy Derivative of Chalcon

Abstract

In this work, a study of the protective properties of a new hydroxy derivative of chalcone was carried out in comparison with a water-soluble analogue of vitamin E - trolox. The inhibitory activity of the compounds was evaluated on a model system of the long-term process of lipid peroxidation in Siberian sturgeon sperm without and with the addition of a cryo-medium. The prolonged antioxidant activity of chalcone, comparable with the action of the reference compound, was established. An increase in the time of sperm motility in the presence of the compounds under study, while maintaining a survival rate of 100%, allows us to consider the hydroxy derivative of chalcone as an potential cryoprotectant.