Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

Samar, Elblehi S.; Samah, Oda S.; Hossam, Tohamy G.; El-sayed, Elmanakhly M.

doi:10.5455/ajvs.203149

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Elblehi 21 who reported that histopathological examinations of rat's brain in cypermethrin with vitamin-E treated group showed mild lesion, which was seen as neuronal vacuolation.…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin-E on cypermethrin induced toxicity in cerebral cortex of wistar albino rats: A histological study

Mahat

Jha

Shrestha

et al. 2020

J. Karnali Acad. Health Sci.

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Backgrounds: Cypermethrin, class II pyrethroid pesticides, is commonly used in the agricultural field and house pest controls. Cypermethrin leads to neurotoxicity by crossing the blood-brain barrier, inducing oxygen stress in brain tissue. Vitamin-E is an antioxidant, involving in protecting membrane stability against free radicals induced peroxidants. This study was conducted to see the protective effect of vitamin-E on cypermethrin induced toxicity. Methodology: Fifty healthy Wistar albino rats of either sex weighing 150-200 grams were randomly selected & divided into five groups. Rats in first group served as control. Rats in second and fourth group were given cypermethrin orally at 20 mg/kg/BW for 14 and 28 days respectively. Rats in third and fifth group were give cypermethrin plus vitamin-E 2.5 ml/kg/BW orally for 14 and 28 days respectively. Rats were sacrificed and the brain was removed. Tissue processing was done. Histological analysis was carried out and statistical analysis was performed by the use of SPSS. Result: Cypermethrin treated rats showed decreased body and brain weight with severe neuronal vacuolation and decrease glial cell. While cypermethrin plus vitamin-E treated group showed increased body and brain weight, with normal glial cell and mild neuronal changes were observed. Conclusion: Cypermethrin in combination with vitamin-E minimized its harmful effect which was evidenced by improving body and brain weight gain and histological changes.

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“…Elblehi 21 who reported that histopathological examinations of rat's brain in cypermethrin with vitamin-E treated group showed mild lesion, which was seen as neuronal vacuolation.…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin-E on cypermethrin induced toxicity in cerebral cortex of wistar albino rats: A histological study

Mahat

Jha

Shrestha

et al. 2020

J. Karnali Acad. Health Sci.

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show abstract

“…، ‫از‬ ‫استير‬ ‫كولين‬ ‫اسيتيل‬ ‫يم‬ ‫إنز‬ ‫لتثبيط‬ ‫باإلضافة‬ ‫ة‬ ‫الحر‬ ‫الجذور‬ ‫عدد‬ ‫يادة‬ ‫وز‬ (Sharma et al, 2014) ‫عند‬ ‫الحركة‬ ‫انتظام‬ ‫عدم‬ ‫إلى‬ ‫ى‬ ّ ‫أد‬ ‫أنه‬ ‫كما‬ ، ‫ان‬ ‫الفئر‬ ‫إناث‬ ‫عند‬ ‫األلم‬ ‫حساسية‬ ‫انخفاض‬ ‫و‬ ‫الذكور،‬ (Yavuz et al, 2009) ‫القلب‬ ‫و‬ ‫الدماغ‬ ‫و‬ ‫الكلى‬ ‫و‬ ‫الكبد‬ ‫في‬ ‫نسيجيه‬ ‫ات‬ ‫ر‬ ّ ‫تغي‬ ‫ب‬ ّ ‫وسب‬ ، (Elblehi et al, 2015) . ‫من‬ ‫وسلوكية‬ ‫عصبية‬ ‫ا‬ ‫ار‬ ‫أضر‬ ‫المبيدات‬ ‫تسبب‬ ‫از،‬ ‫استير‬ ‫كولين‬ ‫يم‬ ‫انز‬ ‫تثبيط‬ ‫خالل‬ ‫المزمن‬ ‫أو‬ ‫الحاد‬ ‫التسمم‬ ‫خالل‬ ‫ومن‬ ‫منخفضة‬ ‫بجرعات‬ (Miranda et al, 2002) ‫سببت‬ (Junqueira & Carneiro, 2006) .…”

Section: ‫بحـوث‬unclassified

Effects of Alpha Cypermethrin on physico-chemical properties of water and the tissue structure of the cerebellum in Taeniopygia guttata

Attal¹,

Shaghouri²,

Kassem³

2019

AJPP

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Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches

Elblehi,

Hafez,

El-Far

2023

Environ Sci Pollut Res

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Cypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and various pest eradication programs. However, it induces numerous health hazards for animals and humans. Therefore, the current study used Panax ginseng root extract (ginseng) to reduce the hepatorenal damage caused by commercially used CYP. Thirty-two male Wistar albino rats were distributed into control, ginseng (300 mg/kg B.W/day), CYP (4.67 mg/kg B.W.), and Ginseng+CYP (rats received both CYP and ginseng). All treatments were administered orally for 30 consecutive days. Cypermethrin induced harmful effects on hepatic and renal tissues through a substantial decline in body weight in addition to a considerable increase in liver enzymes, functional renal markers, and cholesterol. Also, CYP significantly decreased acetylcholinesterase (AChE) activity and increased pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)). Moreover, a marked increase in malondialdehyde level with a significant drop in reduced glutathione level and total superoxide dismutase (T-SOD) and catalase (CAT) activities was reported in the CYP group in kidney and liver tissues. Additionally, CYP exhibited affinities to bind and inhibit AChE and antioxidant enzymes (T-SOD and CAT) in rats following the molecular docking modeling. The apparent hepatorenal oxidative damage was linked with obvious impairments in the liver and kidney histoarchitecture, immunohistochemical staining of B cell lymphoma-2 (Bcl-2), and caspase-3 proteins. Ginseng reduced CYP’s oxidative alterations by repairing the metabolic functional markers, improving antioxidant status, reducing the inflammatory response, and enhancing the molecular docking evaluation. It also ameliorated the intensity of the histopathological alterations and improved the immunohistochemical staining of Bcl-2 and caspase-3 proteins in the liver and kidney tissues. Finally, concomitant oral administration of ginseng mitigated CYP-prompted hepatorenal damage through its antioxidant, anti-inflammatory, and anti-apoptotic potentials. Graphical Abstract

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Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

Cited by 3 publications

References 33 publications

Effect of vitamin-E on cypermethrin induced toxicity in cerebral cortex of wistar albino rats: A histological study

Effect of vitamin-E on cypermethrin induced toxicity in cerebral cortex of wistar albino rats: A histological study

Effects of Alpha Cypermethrin on physico-chemical properties of water and the tissue structure of the cerebellum in Taeniopygia guttata

Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches

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