Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats

Ourique, Giovana M.; Saccol, Etiane M.H.; Pês, Tanise S.; Glanzner, Werner Giehl; Schiefelbein, Sun Hee; Woehl, Viviane Mara; Baldisserotto, Bernardo; Pavanato, María A.; Gonçalves, Paulo Bayard Dias; Barreto, Kátia Padilha

doi:10.1016/j.fct.2016.07.011

Cited by 51 publications

(36 citation statements)

References 66 publications

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“…Such activities may be the actions of high caratenoids, especially lycopene and b-carotene contents (Aoki et al, 2002;Kubola et al, 2013) and vitamin E (Vuong le et al, 2002). Therefore, MC aril extract containing high antioxidant capacity could prevent adverse reproductive parameters of VPA-treated rats as previously reported (Hamza & Amin;Sakr et al;Iamsaard et al;Ourique et al, 2016) via oxidative pathways. The biochemical and molecular analyses were performed to explain additional mechanisms of how the MC could prevent such adverse effects.…”

Section: Discussionmentioning

confidence: 58%

“…However, the mechanism of MC action on the upregulation of StAR and AR proteins is still unknown. Previous reports have explained that the action of VPA is involved in oxidative stress in male reproductive system (Hamza & Amin;Khan et al, 2011;Ourique et al) by causing testicular DNA damage (Sakr et al;Durairajanayagam et al, 2014). All together with previous reports, MC is an antioxidant plant that has efficacy to prevent the oxidative stress form VPA treatment.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

et al. 2017

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SITTHICHAI, I.; WANNISA, S.; APICHAKARN, S. & BUNGORN, S.Protective effect of Momordica cochinchinensis (L.) spreng aril extract on essential testicular markers in rats induced with valproic acid. Int. J. Morphol., 35(3):992-999, 2017. SUMMARY:Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before coadministration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and expression of androgen receptor (AR), Ki-67, tyrosine phosphorylated proteins, and steroidogenic proteins in testis were examined. The results showed that MC could prevent all reproductive parameters in VPA-treated rats. Moreover, MC+VPA groups showed significant declining of testicular histopathologies compared to VPA group. It also decreased the malondialdehyde level and changes of the testicular StAR, AR, and tyrosine phosphorylated protein expressions. In conclusion, M. cochinchinensis aril extract can prevent adverse male reproductive parameters and essential testicular proteins damages induced with VPA.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

et al. 2017

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“…Unlike other cells, spermatozoa are particularly susceptible to oxidative stress due to low cytoplasmic content and high level of polyunsaturated fatty acids in their membrane. Considering lipophilic attributes of Vit E and its protective role against induced lipid peroxidation by ROS in the sperm membrane, several studies suggested that Vit E can quench progression of lipid peroxidation and improve percentage of motility (Alizadeh et al, 2016;Kessopoulou et al, 1995;Ourique et al, 2016), but most of these studies, have used Vit E with other vitamins or other components, and observed better improvement in percentage of sperm motility (Showell, Mackenzie-Proctor, Jordan, & Hart, 2017). Figure 3, when we used Vit E alone, percentage of sperm DNA damage, and lipid peroxidation did not improve in varicocelized rats at 4 months.…”

Section: Discussionmentioning

confidence: 99%

“…Considering lipophilic attributes of Vit E and its protective role against induced lipid peroxidation by ROS in the sperm membrane, several studies suggested that Vit E can quench progression of lipid peroxidation and improve percentage of motility (Alizadeh et al, 2016;Kessopoulou et al, 1995;Ourique et al, 2016), but most of these studies, have used Vit E with other vitamins or other components, and observed better improvement in percentage of sperm motility (Showell, Mackenzie-Proctor, Jordan, & Hart, 2017). Considering lipophilic attributes of Vit E and its protective role against induced lipid peroxidation by ROS in the sperm membrane, several studies suggested that Vit E can quench progression of lipid peroxidation and improve percentage of motility (Alizadeh et al, 2016;Kessopoulou et al, 1995;Ourique et al, 2016), but most of these studies, have used Vit E with other vitamins or other components, and observed better improvement in percentage of sperm motility (Showell, Mackenzie-Proctor, Jordan, & Hart, 2017).…”

Section: F I G U R E 3 Comparison Of Sperm Functional Tests Between Cmentioning

confidence: 99%

The effect of vitamin E & vitamin B on sperm function in rat varicocele model

et al. 2019

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We assessed the effect of vitamin E and vitamin B (Vit E & Vit B) and their combination on sperm functional parameters in the rat varicocele model. Male rats (n = 120) were divided into control (n = 30), sham (n = 30) and varicocele induction (n = 60) groups. After 2 months, 10 rats from each group were sacrificed to verify varicocele model. This part of results showed that sperm parameters, DNA damage, lipid peroxidation and residual histone were adversely effected in the varicocele group. From the 50 remaining rats in varicocele group, 10 rats received Vit B complex (6, 9.6, 30.4, 9.6 and 0.006 mg/kg for B6, B2, B9, B1 and B12 respectively), 10 rats received Vit E (40 mg/kg), 10 rats received Vit B & E, 10 rats only received water and 10 rats were only received sesame oil as a solvent for Vit E, for 2 months. From 40 remaining rats in control and sham groups, 20 rats only received water and other 20 rats only received sesame oil for 2 months. Then, all the aforementioned parameters were assessed. These results showed that Vit B antioxidant was more efficient in improvement of sperm parameters, chromatin integrity and lipid peroxidation in varicocelized rats compared with Vit E.

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“…Environmental exposure to pro‐oxidant factors, during a vital period of pre‐ and post‐pregnancy such as valproic acid (VPA), mercury, air pollutants, thalidomide, and retinoic acid can serve as triggering factors of oxidative stress in autism (Ourique et al, 2016; Tchaconas and Adesman, 2013). According to recent research, VPA is one of the best models for creating autism symptoms in rodents (Brudzynski, 2013; Schneider and Przewłocki, 2005).…”

Section: Introductionmentioning

confidence: 99%

Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido‐inflammatory stress in rat model of autism

Khalaj

Moghaddam

Zare

2018

Intl J of Devlp Neuroscience

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Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs). The aim of this study was to investigate the comparative effects of hesperetin (Hst) and nano-hesperetin on social behavior deficits and oxido-inflammatory indexes in prenatally valproic acid-exposed rat offspring. Pregnant Wistar rats on embryonic day 0 (E0) were segregated into six groups; Group-1 served as vehicle, received distillated water orally (PO) from E1 until the end of lactation and saline intraperitoneally (i.p) on E12.5. Group-2 received sodium valproate (500 mg/kg in 0.9% saline, i.p) on E12.5 was considered as VPA-exposed group, Group-3 to 6 were VPA-exposed which received hesperetin and nano-hesperetin (10 and 20 mg/kg/day, PO) from E0 until the end of lactation respectively. Social interaction and open field tests were conducted on postnatal day 28 (PND 28) and PND 30, cerebral antioxidant enzymes activity and biochemical indexes, the level of inflammatory factors in plasma and histopathology of cerebellum were estimated on PND 28 and PND 30. Prenatal valproic acid-exposed rat exhibited poor sociability and high level of anxiety-like behaviors (P < 0.05). In addition, increased level of oxidative stress and inflammation were found by determining different oxido-inflammatory markers. Hesperetin and nano-hesperetin treatment improved the behavioral disorder and reduced the oxidative stress in brain and significantly (p < 0.05) plasma's inflammation indexes. In conclusion, it can be state that nano-hesperetin exerts neuroprotective action in comparison with hesperetin and could be efficacious for treatment of VPA animal model of autism during pregnancy and lactation.

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Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats

Cited by 51 publications

References 66 publications

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

The effect of vitamin E & vitamin B on sperm function in rat varicocele model

Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido‐inflammatory stress in rat model of autism

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