Protective effects of a compound isolated from Alnus japonica on oxidative stress-induced death in transformed retinal ganglion cells

Jo, Hyoung; Choi, Soon Jung; Jung, Sang Hoon

doi:10.1016/j.fct.2013.02.052

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…The cells were stained with Hoechst 33342 (8 μM) with or without PI (1.5 μM) for 30 min at 37 °C to measure apoptotic or necrotic cell death caused by glutamate plus BSO2526. After being washed twice, the cells were imaged using a fluorescence microscope (Olympus, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

Ahn

Kim

Kang

et al. 2017

Sci Rep

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Retinal ganglion cell (RGC) death is part of many retinal diseases. Here, we report that the ethanol extract of Diospyros kaki (EEDK) exhibits protective properties against retinal degeneration, both in vitro and in vivo. Upon exposure to cytotoxic compounds, RGC-5 cells showed approximately 40% cell viability versus the control, while pre-treatment with EEDK markedly increased cell viability in a concentration-dependent manner. Further studies revealed that cell survival induced by EEDK was associated with decreased levels of apoptotic proteins, such as poly (ADP-ribose) polymerase, p53, and cleaved caspase-3. In addition to apoptotic pathways, we demonstrated that expression levels of antioxidant-associated proteins, such as superoxide dismutase-1, glutathione S-transferase, and glutathione peroxidase-1, were positively modulated by EEDK. In a partial optic nerve crush mouse model, EEDK had similar ameliorating effects on retinal degeneration resulting from mechanical damages. Therefore, our results suggest that EEDK may have therapeutic potential against retinal degenerative disorders, such as glaucoma.

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Section: Methodsmentioning

confidence: 99%

Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

Ahn

Kim

Kang

et al. 2017

Sci Rep

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“…Hirsutenone ( 73 ) was able to protect retinal ganglion cells from oxidative stress-induced death. Therefore, it was considered to be a neuroprotective agent for the treatment of neurodegenerative disease, such as glaucoma [ 137 ]. The methanol extract of A. glutinosa subsp.…”

Section: Biological Activitiesmentioning

confidence: 99%

The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities

et al. 2017

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The genus Alnus (Betulaceae) is comprised of more than 40 species. Many species of this genus have a long history of use in folk medicines. Phytochemical investigations have revealed the presence of diarylheptanoids, polyphenols, flavonoids, terpenoids, steroids and other compounds. Diarylheptanoids, natural products with a 1,7-diphenylheptane structural skeleton, are the dominant constituents in the genus, whose anticancer effect has been brought into focus. Pure compounds and crude extracts from the genus exhibit a wide spectrum of pharmacological activities both in vitro and in vivo. This paper compiles 273 naturally occurring compounds from the genus Alnus along with their structures and pharmacological activities, as reported in 138 references.

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Phyllanthus emblica L. (Indian gooseberry) extracts protect against retinal degeneration in a mouse model of amyloid beta-induced Alzheimer’s disease

Jang

Srichayet

Park

et al. 2017

Journal of Functional Foods

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Protective effects of a compound isolated from Alnus japonica on oxidative stress-induced death in transformed retinal ganglion cells

Cited by 4 publications

References 31 publications

Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities

Phyllanthus emblica L. (Indian gooseberry) extracts protect against retinal degeneration in a mouse model of amyloid beta-induced Alzheimer’s disease

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