Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet‐induced photodamage in human skin

Oresajo, Christian; Stephens, Thomas M.; Hino, Peter; Law, Robert M.; Yatskayer, Margarita; Foltis, Peter; Pillai, Sreekumar; Pinnell, Sheldon R.

doi:10.1111/j.1473-2165.2008.00408.x

Cited by 137 publications

(118 citation statements)

References 33 publications

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“…The recent findings that phloretin and some of its derivatives have potent antiinflammatory (32), antioxidative (33,45), and even some anticancer (35,46) activities form the scientific basis for the common saying ''an apple a day keeps the doctor away.'' Phloretin has also been successfully evaluated as a penetration enhancer for transdermal drug delivery (27-31) and as skin protectant reducing oxidative stress resulting from external insults, such as UV irradiation, which triggers skin cancer and photo aging (33,34,47). Recent studies in rodents have confirmed that dermal administration of phloretin will systemically spread in the animal (28), and that phloretin has a rather short half-life in vivo (48).…”

Section: Discussionmentioning

confidence: 99%

“…Phloretin has been studied as a possible penetration enhancer for skin-based drug delivery (27)(28)(29)(30)(31), attenuates inflammation by antagonizing prostaglandins (32), protects the skin from UV light-induced photodamage (33,34), and is currently evaluated as a chemopreventive agent for cancer treatment (35). Because the plant rhizosphere is one of the natural habitats of Pseudomonas putida (strain DOT-T1E), this prokaryote has evolved the RND family transporter TtgABC with multidrug recognition properties, which is controlled by its cognate repressor TtgR binding to a specific operator (O TtgR ) in the TtgR promoter (P TtgR ).…”

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confidence: 99%

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Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Gitzinger

Kemmer

El‐Baba

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

101

109

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Adjustable control of therapeutic transgenes in engineered cell implants after transdermal and topical delivery of nontoxic trigger molecules would increase convenience, patient compliance, and elimination of hepatic first-pass effect in future therapies. Pseudomonas putida DOT-T1E has evolved the flavonoid-triggered TtgR operon, which controls expression of a multisubstrate-specific efflux pump (TtgABC) to resist plant-derived defense metabolites in its rhizosphere habitat. Taking advantage of the TtgR operon, we have engineered a hybrid P. putida-mammalian genetic unit responsive to phloretin. This flavonoid is contained in apples, and, as such, or as dietary supplement, regularly consumed by humans. The engineered mammalian phloretin-adjustable control element (PEACE) enabled adjustable and reversible transgene expression in different mammalian cell lines and primary cells. Due to the short half-life of phloretin in culture, PEACE could also be used to program expression of difficult-to-produce protein therapeutics during standard bioreactor operation. When formulated in skin lotions and applied to the skin of mice harboring transgenic cell implants, phloretin was able to fine-tune target genes and adjust heterologous protein levels in the bloodstream of treated mice. PEACE-controlled target gene expression could foster advances in biopharmaceutical manufacturing as well as gene-and cell-based therapies.synthetic biology ͉ synthetic gene networks ͉ transdermal gene regulation ͉ gene therapy ͉ biopharmaceutical manufacturing

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Gitzinger

Kemmer

El‐Baba

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

101

109

View full text Add to dashboard Cite

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“…The results showed that the antioxidant mixture lotion provided significant photoprotection for skin according to all evaluation methods and its mechanism of action is different from sunscreens, suggesting that they can be used as a supplement to conventional sun protectors (Murray et al, 2008). Oresajo et al (2008) evaluated the protective effects of a topical antioxidant mixture containing vitamin C, FA and phloretin against ultraviolet-induced photodamage in human skin using biomarkers of skin damage. Ten human subjects (18-60 years old; Fitzpatrick skin types II and III) were randomized and treated with the antioxidant product or vehicle control on the lower back for four consecutive days.…”

Section: Uv Protection Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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“…Burke [7] reviews studies of combinations of vitamins C and E, concluding that the synergy in UV protection arises from the mutual regeneration of the vitamins. Murray et al [8] and Oresajo et al [9] in a follow up study to Lin [10] (all publications from Pinnell's laboratory) show the in vivo protective effect of stabilized topical antioxidant blends containing vitamin C, ferulic acid, and either phloretin or tocopherol.…”

Section: Vitaminsmentioning

confidence: 98%

Benefits of Anti-Aging Actives in Sunscreens

Lintner

2017

Cosmetics

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Sunscreens are functional, utilitarian, cosmetic products. The criteria of purchase are different from those for skin care and make-up. Companies are trying to add glamour and value to basic sunscreens by incorporating "active" ingredients (other than UV filters) into these formulas and by communicating about the additional benefits, be they anti-aging, moisturizing, firming, anti-wrinkle, etc. While some of these ideas of additional ingredients make sense as supplementary skin protection, some others do not afford much benefit in view of the infrequent application and short period of usage. The present article reviews some of these ideas and presents a few active ingredients that might be of value in such a context, even if substantiation of such additional claims in sunscreens is often lacking.

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Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet‐induced photodamage in human skin

Cited by 137 publications

References 33 publications

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Benefits of Anti-Aging Actives in Sunscreens

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