Protective Effects of Antioxidant Medications on Limb Ischemia Reperfusion Injury

Bolcal, Cengiz; Yıldırım, Vedat; Doğancı, Suat; Sarğın, Murat; Aydın, Ahmet; Eken, Ayşe; Özal, Ertuğrul; Kuralay, Erkan; Demirkılıç, Ufuk; Tatar, Harun

doi:10.1016/j.jss.2006.10.043

Cited by 59 publications

(44 citation statements)

References 18 publications

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“…Liu et al noted a similar protective effect after IRI as measured by improved arteriolar dilatation and tetanic contraction [30]. NAC also decreases muscle cell death attributable to IRI in mice as measured by malonyldialdehyde levels [8]. Thus, the apparent benefits of NAC seen in IRI models apparently apply in our CS model.…”

Section: Discussionsupporting

confidence: 64%

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Kearns

O’Briain

Sheehan

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Section: Discussionsupporting

confidence: 64%

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Kearns

O’Briain

Sheehan

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…Postischemic endothelium is the main source for the free radicals 56 . It is known that the most impairing effect of free oxygen radicals is peroxidation of polyunsaturated fatty acids in the cell membrane [57][58][59] .…”

Section: Resultsmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg À1 dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.

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“…Prohibition of free radical genesis and the inactivation of the already occurred radicals are the main objective of cellular antioxidant defence mechanisms, which includes various enzymatic mechanisms (39). Glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) are important and well-known antioxidant enzyme systems which participate in the endogenous defence system against free radicals (25,40). Cigarette smoking is described in the literature to be a risk factor for the formation of free radicals which may affect pregnant women and their infants.…”

Section: Discussionmentioning

confidence: 99%

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

Aydoğan

Durmaz

Ercan

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Some of the genotoxic/carcinogenic substances or metabolites in cigarette smoke are capable of passing through the placenta and harming a newborn's health. Smoking is also known as a factor in the formation of oxidative damage and the main mechanism involved in the carcinogenic process. Predetermining this genotoxic risk can be successfully achieved by measuring certain parameters of oxidative stress. The comet assay is considered an important biomarker for the evaluation of genotoxic substances and is effective for detecting DNA damage caused by smoking. This study examined third trimester bloods and the cord blood of 28 actively smoking and 22 non-smoking mothers in terms of DNA damage and oxidative stress parameters. Cu/Zn superoxide dismutase (CuZn-SOD), malondialdehyde (MDA), catalase (CAT), plasma nitrite/nitrates (NO 2 -/NO 3 -), selenium-dependent glutathione peroxidase (Se-GPx), Cu, and Zn levels were measured as indicators of oxidative damage. There were no signifi cant increases in DNA damage of the actively smoking pregnant group in comparison with the non-smoking pregnant group, either in the third trimester or cord blood. Oxidative stress parameters of smoker and non-smoker groups were statistically different for MDA (p<0.05), CuZn-SOD (p<0.01), Se-GPx (p<0.05) values while the difference was not signifi cant for NO 2 -/NO 3 -, CAT, Zn, and Cu values. The same values were also investigated in cord blood, and only NO 2 /NO 3 -(p<0.01), Se-GPx (p<0.01 and CAT (p<0.001) values were found statistically different. Smoking mothers may have been exposed to more oxidative stress than non-smoking mothers.

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Protective Effects of Antioxidant Medications on Limb Ischemia Reperfusion Injury

Cited by 59 publications

References 18 publications

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

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