Protective effects of baicalin on ligature‐induced periodontitis in rats

Cai, Xinjie; Li, Chengzhang; Du, Ge-Fei; Cao, Zhengguo

doi:10.1111/j.1600-0765.2007.00989.x

Cited by 104 publications

(101 citation statements)

References 39 publications

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“…Similarly, beneficial effect has been also reported for different polyphenols [80][81][82][83][84]87 , as well as CoQ 99 but they only have been tested in animals, although for many their in vivo antioxidant effects seems due to iNOS expression or activity modulation and not to free radical scavenging. Unfortunately, at the moment, experimental interventions in humans have been reduced to vitamin C 54-57 but also for E 76 or Zinc 78 , where vitamin E have result the most interesting although it were used after mechanical treatment.…”

Section: Coenzyme Qmentioning

confidence: 74%

“…The additon of several specific polyphenols to the diet have been tested in rodents models of periodontitis. In rat models of ligatureinduced periodontitis oral administration of resveratrol (trans-3,4ʹ,-5-trihydroxystilbene) 80,81 , mangiferin (C2-b-dglucopyranosyl-1,3,6,7-tetrahydroxyxanthone) 82 , baicalin (7-glucuronic acid, 5,6-dihydroxy-flavone) 83 , verbascoside (4,5-hydroxyphenylethanol bound to a b-(d)-glucopyranoside) and quercetin (3,5,7,3ʹ,4ʹ-pentahydroxyflavone) 84 have…”

Section: Polyphenolsmentioning

confidence: 99%

“…Similar effect on alveolar bone has been observed in a mouse periodontitis model induced by A. actinomycetemcomitans infection for the compound 84 . Additionally, when it was measured, it was noted that this effect on bone loss correlates with reduced oxidative stress 87 or levels of enzymes that promote it like iNOS 83,87 . In particular, quercetin has shown a clear antioxidant effect in the oral cavity against NO resulting from nitrite reduction by certain oral bacteria which could extend to other compound of this type 88 .…”

Section: Polyphenolsmentioning

confidence: 99%

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Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

et al. 2015

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LICENSE 3.0 UNPORTED. RESUMENObjetivos. Dada la relación existente entre periodontitis crónica y altos niveles de estrés oxidativo, esta revisión pretende clarificar qué papel puede desempeñar la ingesta de los diferentes antioxidantes de la dieta en el mantenimiento de un periodonto saludable y en la reducción del riesgo de padecer periodontitis crónica, así como el posible uso de terapias dietéticas basadas en estos para el tratamiento de dicha enfermedad.Métodos. Se utilizó la base de datos de la National Library of Medicine, Washington, DC (MEDLINE: PubMed) y todos los estudios en animales y humanos tratando el tema de interés en escritos Inglés disponibles online desde la creación de la base de datos hasta Mayo de 2015 fueron recopilados.Resultados. Los antioxidantes analizados a este respecto incluyen a la vitamina C, la vitamina A, algunos carotenoides y polifenoles, y el coenzima Q; así como los minerales, hierro, cobre y zinc que forman parte de enzimas antioxidantes. Aun así hay una escasez generalizada de estudios con pocos estudios en humanos, la mayoría de tipo observacional. Entre los diferentes antioxidantes, la vitamina E y los polifenoles parecen ser los que más evidencias a favor de su efecto beneficioso suman, pero en general los estudios son insuficientes para descartar o establecer qué antioxidantes son útiles y cuáles no.Conclusiones. En general, los datos presentados indicarían que los antioxidantes de la dieta resultan beneficiosos para la salud periodontal, al menos bajo ciertas circunstancias. Sin embargo se necesitan más estudios para establecer la relación entre la periodontitis crónica y cada antioxidante concreto así como para diseñar intervenciones dietéticas útiles en la gestión de esta enfermedad. Methods. The database of the National Library of Medicine, Washington, DC (MEDLINE PubMed) was used and all the studies in animals and humans are on the subject of interest in English writing online available from inception of the database until May 2015 were collected.Results. Antioxidants analyzed in this regard include vitamin C, vitamin A, carotenoids and some polyphenols, and coenzyme Q; as well as minerals iron, copper and zinc that are constituents of antioxidant enzymes. Still, there is a paucity of studies with few human studies, mostly observational. Among the various antioxidants, vitamin E and polyphenols seem to have more evidence for its beneficial effect, but Artículo de revisión Review Article Correspondencia CorrespondenceJosé Luis Quiles Morales, Centro de Investigación Biomédica (CIBM), Lab. 250. Universidad de Granada, Avda. del Conocimiento s.n., 18100 Armilla, Granada, España. E-Mail: jlquiles@ugr. es; Tel.: +34958241000 (ext. 20316). Financiación FundingsTrabajo realizado sin financiación. Conflicto de interés Competing interest No hay conflicto de intereses Agradecimientos AcknowledgementsLos autores agradecen a la Junta de Andalucía y a la Universidad de Granada por el continuo soporte al grupo de investigación. Alfonso Varela López es contratado FPU del Ministe...

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Section: Coenzyme Qmentioning

confidence: 74%

Section: Polyphenolsmentioning

confidence: 99%

Section: Polyphenolsmentioning

confidence: 99%

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Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

et al. 2015

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“…Dental plaque and calculus are considered to be the main causes of these lesions (Cai et al 2008, Varoni et al 2012. A dentifrice containing flavonoids showed to be beneficial when tested in rats against gingival oxidative stress and periodontal inflammation (Maruyama et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Kalanchoe gastonis-bonnieri extract to control bacterial biofilms and dental calculus in dogs

et al. 2017

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RESUMO.-[Eficácia do extrato de Kalanchoe gastonis--bonnieri no controle do biofilme bacteriano e cálculo dentário em cães.] Um extrato aquoso de folhas da espé-cie medicinal Kalanchoe gastonis-bonnieri (aqui denominado como KGB) foi efetivo como um agente antimicrobiano contra as bactérias da cavidade oral de cães em testes in vitro. Neste estudo, investigou-se o efeito da administração oral tópica de KGB sobre o desenvolvimento do biofilme dental em cães da raça Beagle. Os experimentos foram realizados com um grupo experimental (0,2% de extrato de KGB), um grupo controle negativo (0,9% de solução salina) e um grupo controle positivo (0,12% de gluconato de clorexidina). Cada tratamento foi aplicado no interior da ca- An aqueous leaf extract of the medicinal species Kalanchoe gastonis-bonnieri (here denominated KGB) has been found to be effective as an antimicrobial agent against canine oral cavity bacteria in in vitro assays. In this study, we investigated the effect of topic oral administration of KGB on the development of dental biofilm in Beagle dogs. The experiments were performed with an experimental group (0.2% of KGB extract), a negative control group (0.9% of saline solution) and a positive control group (0.12% chlorhexidine). Each treatment was sprayed into the oral cavity daily for 28 days. Thirty Beagle dogs with similar characteristics and kept under the same management and diet were used. The measurement of dental plaque and calculus was performed using a computerized analytical method. The phenolic profile of KGB extract was analyzed by HPLC-DAD. KGB extract at 0.2% showed efficacy in controlling the formation of plaque compared to the negative control group, and dental calculus in relation to the negative and positive control groups. A significant difference was observed among these three groups. Peaks attributed to flavonoids and phenolic acids were identified in the HPLC-DAD chromatogram of the KGB extract. The presence of these substances could be related to the activity observed. Our findings demonstrate that treatment with KGB is effective in controlling periodontal disease in dogs, providing new insights into the medicinal properties of this plant. KGB extract has a potential use as a supplemental agent in pharmaceutical products for the prevention of periodontal disease. Efficacy of aINDEX TERMS: Kalanchoe gastonis-bonnieri, plant extract, bacterial biofilm, dental calculus, dogs, periodontal disease, dental plaque, flavonoids. TERMOS DE INDEXAÇÃO:Kalanchoe gastonis-bonnieri, extrato de plantas, biofilme bacteriano, cálculo dentário, cães, doença periodontal, cálculos dentários, placa bacteriana, flavonoides.

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“…13,[19][20][21][22] In this context, it has been evidenced that OB 1493 presented effective anti-bacterial activity in vitro (unpublished data). However, until now, there has been no information available in the literature as regards the effect of OB 1493 on experimental periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

et al. 2012

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Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats Abstract: The aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group -vehicle-treated (n = 18), and Test Group -OE 1493-treated (n = 18). The rats were sacrificed on the 12 th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single-and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study.

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Protective effects of baicalin on ligature‐induced periodontitis in rats

Cited by 104 publications

References 39 publications

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

Efficacy of a Kalanchoe gastonis-bonnieri extract to control bacterial biofilms and dental calculus in dogs

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

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