Protective effects of bone morphogenetic protein 7 against amyloid-beta induced neurotoxicity in PC12 cells

Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid β-induced apoptosis in neuroblastoma cells

“…GSK3β is a protein kinase that also has regulatory effects on neuronal survival and plasticity. Previously, a study indicated that GSK3β may play a part in AD and that its deregulation may account for a number of the pathological hallmarks of AD (11). …”

Roles of BMP6/7 in Actin Dynamics in Amyloid β-Induced Neurotoxicity

“…Recently, it has been shown that BMP6/7 can affect neurogenesis, axonal pathfinding, and dendritic branching during development of nervous system (Garred et al, 2011;Di Liddo et al, 2010). On the other hand, BMP6/7 can protect mature neurons against Aβ-induced neurodegenerative stress (Sun et al, 2011). Bone morphogenetic protein receptors (BMPRs) are transmembrane serine/threonine protein kinases that belong to the receptors of TGF-β family and consist of BMP receptor type I (BMPRI) and BMP receptor type II (BMPRII).…”

“…It has been reported that the protective effects of BMP7 on Aβ-induced neurotoxicity involve decreasing cell morphology damage and maintaining dendrites outgrowth (Sun et al, 2011), which are mainly attributed to the stability of intracellular actin filaments. As shown in Figure 2, the possible mechanism underlying BMPs reducing Aβ-induced cytoskeleton impairment in dendrites may involve release of BMPRII C-terminal and reactivation of LIMK1, leading to phosphorylation of ADF/cofilin and reassembly of F-actin.…”

“…BMP7 can protect human disc cells against apoptosis through inactivation of caspases-3 (Wei et al, 2009), and reduces lesion volume in injured spinal cord (Enzmann et al, 2005). Our previous experiments have shown that BMP7 protects neuron viability and morphology of dendrites against Aβ-induced neurotoxicity (Sun et al, 2011); however, further study is warranted to better understand the detailed mechanisms. Here we reviewed Aβ neurotoxicity-induced pathological changes in the aspect of actin dynamics, the changes of BMP upstream regulatory pathways, and the mechanism underlying BMP6/7 protecting morphology of dendrites from Aβ-induced neurotoxicity.…”

“…Bone morphogenetic proteins (BMPs), a member of the β-transforming growth factor (TGF-β) subfamily, are synthesized as precursor proteins, proteolytically cleaved at the N-terminus and secreted into the extracellular matrix (Sun et al, 2011). BMPs are originally found as a cartilage anabolic factor, which can induce matrix synthesis and promote fracture healing (Doi et al, 2011).…”