Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

Bahadoran, H; Naghii,; Mofid, Mahmood; Asadi, MH; Ahmadi, Khodabakhsh; Sarveazad, Arash

doi:10.1515/enr-2016-0021

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…Ethylene glycol is commonly used to form nephrolithiasis model in rats to simulate the formation of kidney stones in humans [ 32 ]. Nephrolithiasis was evidenced by both microscopic urine analysis and kidney histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis

et al. 2021

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Aim Nephrolithiasis is a chronic metabolic condition affecting 10% of population worldwide. The present study aimed to investigate the possible protective role of candesartan (CAND) and sodium thiosulfate (STS) in ameliorating ethylene glycol (EG) induced nephrolithiasis. Methods One hundred male Wistar rats were divided into five groups: Normal control group, nephrolithiasis (EG) group (1% EG in drinking water), Cystone (CYS) group (EG + 750 mg/kg CYS, orally, once daily), STS group (EG + 0.4 gm/kg STS, intraperitoneally, 3 times/week) and CAND group (EG + 70 μg/mL CAND in drinking water). Treatments and EG administration commenced on the same day and continued for 28 days. CYS was used as reference drug. Urine, blood, and renal tissues were collected at the end of the experiment for assessment of kidney function tests (serum creatinine and urea), urinary (8-hydroxydeoxyguanosine (8-OHdG), calcium and oxalate), inflammatory and oxdative stress biomarkers (transforming growth factor beta (TGF-β), osteopontin (OPN) and ratio of reduced glutathione to oxidized glutathione (GSH/GSSG)) in renal tissue. Results Serum (creatinine and urea), urinary (8-OHdG and oxalate) and renal (OPN and TGF-β) were significantly reduced in CAND and STS groups compared to EG group. Furthermore, renal GSH/GSSG and urinary calcium were significantly increased in CAND and STS groups compared to EG group. Histopathological results support the biochemical findings; CAND and STS groups showed less retention of crystals and necrotic damage in kidney. Also, microscopic examination of urine revealed less crystal for CAND and STS groups. Conclusion Candesartan and sodium thiosulfate exhibited protective effect against nephrolithiasis.

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Section: Discussionmentioning

confidence: 99%

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis

et al. 2021

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“…12 Boron, is an element that decreases the cellular damage caused by oxidative stress (OS). 13 Free radicles (FRs) initiate cell reactive oxygen species (ROS) induced cell damage and cell death. 14 Cerium oxide (CeO2) also has an antibacterial activity 15 due to the redox potential of CeO2, the oxidation state of Ce changed from Ce 3+ and Ce 4+ depending on the external environment, this redox potential facilitates the inhibiting the bacterial growth and scavenging FRs.…”

Section: Methodsmentioning

confidence: 99%

Relationship of some ultra trace elements with atherosclerosis

Moustafa

2019

Zanco J. Med. Sci.

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Background and objective: Trace elements are now measured as possibly having an important role in the pathogenesis of atherosclerosis. This study aimed to investigate the serum rubidium, rhenium, cesium, and boron levels in patients with atherosclerosis as compared with the control group as well as to detect the effect of age and gender and estimate the correlation among the parameters. Methods: This case-control study included 40 patients and 40 apparently healthy adults matched age and gender as a control group. Serum parameter levels were estimated using atomic absorption spectrophotometer. Results: The data of the current study indicated that the levels of rubidium and boron were significantly reduced and there was a significant elevation in the serum level of rhenium while there was no statistical difference in the level of cesium in patients as compared with the control group. In addition, the effect of age and gender did not reveal any significant effect on the serum studied ultra-trace elements levels. There was a negative significant weak correlation between age and Rb (r =-0.38, P = 0.016). Conclusion: Boron and rubidium were significantly reduced; therefore, supplementation could be important for therapy of atherosclerosis.

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“…Recently, it has been suggested that boron inhibits apoptosis by stabilizing the mitochondrial membrane structure (Routray, Ali, 2019). In fact, the mechanisms of boric acid actions (source of boron) on various organs were well documented (Bahadoran et al, 2016;Khaliq et al, 2018). Despite these promising outcomes, additional investigations are strictly needed to elucidate possible mechanisms of the other boron compounds as therapeutic agents.…”

Section: Lithium Tetraborate Reduces the Heart Injury Induced By Rena...mentioning

confidence: 99%

The effect of lithium tetraborate as a novel cardioprotective agent after renal ischemia-reperfusion injury

Koç

Geyikoğlu

Yilmaz

et al. 2022

Braz. J. Pharm. Sci.

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Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as an anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, we employed an in vivo rat model with kidney ischemia reperfusion injury to evaluate cardiac injury to clarify the mechanisms of lithium tetraborate. The evaluation of cardiac injury through kidney artery occlusion and reperfusion rat model indicated that lithium tetraborate could (1) reduce oxidative stress-induced endothelial dysfunction; (2) attenuate the inflammatory response of cardiac cells; and (3) alleviate the apoptosis and necrosis of myocytes. In summary, lithium tetraborate demonstrates significant therapeutic properties that contribute to the amelioration of cardiac damage, and it could be a promising candidate for future applications in myocardial dysfunction.

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Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

Abstract: Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.

Cited by 12 publications

References 38 publications

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis

Relationship of some ultra trace elements with atherosclerosis

The effect of lithium tetraborate as a novel cardioprotective agent after renal ischemia-reperfusion injury

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