Protective Effects of Curcumin against Sodium Fluoride-Induced Toxicity in Rat Kidneys

Abstract

In the present study, the protective effect of curcumin against sodium fluoride-induced nephrotoxicity was evaluated in rats. Renal injury was induced by daily administration of 600 ppm sodium fluoride in drinking water for 1 week. One week before the administration of fluoride, the animals selected as study group were given curcumin (10 and 20 mg/kg body weight, intraperitoneally). After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were measured. Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant. The results show that curcumin and vitamin C treatment prior to fluoride administration normalized the levels of serum creatinine, serum urea, and blood urea nitrogen. Moreover, curcumin and vitamin C administrations prevented the antioxidant enzyme decreasing and lipid peroxidation levels imbalance. In conclusion, curcumin treatment at the doses of 10 and 20 mg/kg (intraperitoneally) showed significant nephroprotective effects.

Protective Effect of Aerobic Exercise Against L-Name-Induced Kidney Damage in Rats

“…These pathophysiological changes were accompanied by a decrease in serum nitrite/nitrate and by downregulation of renal SOD activity, suggestive of high oxidative stress and impairment of antioxidant defences. Earlier studies (3,24,25) have established that NO defi ciencyrelated excessive production of ROS by renal parenchymal cells, resident macrophages, infi ltrating infl ammatory cells, and persistent oxidative stress can impair renal antioxidant defence through inactivation of antioxidant enzymes. Similar changes have been reported in cardiac and/or aortic tissues of L-NAMEtreated rats (14,26).…”

Antioxidant, antihemolytic, and inhibitory activities of endemicPrimula heterochromaagainst Fe2+-induced lipid peroxidation and oxidative stress in rat brainin vitro

“…The volume was made up to 300 µL with water before incubation at 37°C for 1 h. The color reaction was developed by adding 300 µL of sodium dodecyl sulphate (8.1%) to the reaction mixtures containing fractions (Nabavi et al, 2012a).…”

Ameliorative Effects of Quercetin on Sodium Fluoride-Induced Oxidative Stress in Rat’s Kidney

“…However, recent studies estimated that about 20% of pharmaceuticals and 30-40% of agrochemicals are organofluorines. 1 Fluoride-containing compounds are also commonly used in household products and office (e.g., dental products, refrigerants, and fire extinguishers). 2 Prolonged intake of fluoride or excessive consumption results in fluorosis, leading to a progressive degenerative disease, often characterized by dental mottling and skeletal dysfunctions including crippling deformities, osteoporosis, and osteosclerosis.…”

“…2 Prolonged intake of fluoride or excessive consumption results in fluorosis, leading to a progressive degenerative disease, often characterized by dental mottling and skeletal dysfunctions including crippling deformities, osteoporosis, and osteosclerosis. 1 Several studies revealed that fluoride intoxication in the hippocampus of the rat brain can lead to the degeneration of neuronal systems and an alteration of the oxidantantioxidant balance in other organs and tissues. 3 The kidney has a prominent role in fluoride metabolism as 50-80% of fluoride is removed via urinal excretion.…”