2018
DOI: 10.3892/etm.2018.6540
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Protective effects of extracellular polymeric substances from Aphanizomenon�flos‑aquae on neurotoxicity induced by local anesthetics

Abstract: The neurotoxicity of local anesthetics has received an increasing amount of attention and more effective therapeutic agents are required. Extracellular polymeric substances from Aphanizomenon flos-aquae (EPS-A) are high molecular weight polysaccharides. The present study aimed to elucidate the protective effects of EPS-A on neurotoxicity induced by local anesthetics in an intraperitoneal injection bupivacaine rat model. The results of immunohistochemical staining inicated that following intraperitoneal injecti… Show more

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