Protective effects of hydroxytyrosol on gentamicin induced nephrotoxicity in mice

Chashmi, Nooshin Ahmadian; Emadi, Sarvenaz; Khastar, Hossein

doi:10.1016/j.bbrc.2016.12.052

Cited by 22 publications

(13 citation statements)

References 20 publications

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“…One of the primary reasons for the enhanced LPO in the GM group may be GM induced oxidative stress in the cellular environment and the reduction of GSH that subsequently incremented MDA levels. In consistent with our findings, several reports highlighted that natural antioxidants such as eugenol, selenium, hydroxytyrosol, and quercetin included the ameliorative effects on MDA and GSH levels [57].…”

Section: Discussionsupporting

confidence: 93%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM group) received GM (100 mg/kg/day), and group 3 (treated group) received GM (100 mg/kg/day) and GA (100mg/kg/day). All treatments were performed intraperitoneally for 12 days. After 12 days, the rats were euthanized, and kidneys were removed immediately. For serum preparation, blood samples were collected before killing. Kidney paraffin sections were prepared from one of the kidneys and stained by the periodic acid-Schiff process. GA significantly decreased GM-induced renal histopathological injuries, including tubular necrosis, tubular cast, and leucocyte infiltration compared with the GM group. Additionally, GA significantly improved proteinuria, serum levels of urea and creatinine, and serum activities of aspartate aminotransferase (AST) and alanine HIGHLIGHTS  Gallic acid ameliorates gentamicin-induced nephrotoxicity.  Gallic acid decreases levels of NO and MDA and enhances abilities of GSH, GPX, and CAT.  Gallic acid improves altered liver and renal function markers in nephrotoxic animals.  Gallic acid reduces renal histopathological injuries.  2 Ahmadvand, H.; et al.

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Section: Discussionsupporting

confidence: 93%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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“…The damage is secondary to high ROS released. Previous works had also demonstrated an increase in serum concentrations of urea, creatinine and albumin/ creatinine ratio in gentamicin nephrotoxicity 18,26 . This was said to occur as a result of reduction in glomerular filtration rate 27,28 .…”

Section: Resultsmentioning

confidence: 90%

Protective role of dichloromethane extract of solanum dasyphyllumin in gentamicin induced nephrotoxicity in mice

Oyinloye¹,

Aderinola²,

Muritala³

et al. 2020

actapharm

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Gentamicin belong to the aminoglycoside antibiotic, which has a broad spectrum activities against gram positive and gram negative bacteria, but most effective in the treatment of gram negative bacteria. Gentamicin can withstand ABSTRACT This study investigated the effect of dichloromethane extract of Solanum dasyphyllum on gentamicin-induced nephrotoxicity in mice. Thirty mice were randomly divided into six groups (Groups 1-6, 5 each). Nephrotoxicity was induced using 100 mg/kg gentamicin administered intraperitoneally with concomitant administration of different doses of dichloromethane Solanum dasyphyllum extract (SdDMF) (100, 200, and 400mg/kg respectively) orally for 8 days. After the treatment, blood samples were obtained, allowed to clot, and centrifuged to obtain the serum which was used to determine urea, creatinine, and blood urea nitrogen (BUN). Kidney tissue malondialdehyde (MDA) and glutathione (GSH) concentrations; and catalase (CAT) activities were also determined. Result revealed a decrease in tissue MDA, serum creatinine, urea, and BUN in the extract-treated groups. Also, increased tissue CAT activities and GSH concentrations were observed in the extract-treated groups. In conclusion, this study showed that SdDMF can be reno-protective and effectively inhibit gentamicin-induced nephrotoxicity.

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“…We also achieved a similar result by measuring the serum levels of these enzymes as well as the MDA level, and showed that following the injection of gentamicin during a specific period, the level of antioxidant activity was reduced and, as a result, increased MDA levels. Several studies demonstrated incremental changes in serum or urine levels of various compounds such as urea and creatinine, albumin / creatinine ratio (16)(17)(18)(19)(20), due to decreased glomerular filtration rate, as well as NGAL (as a sensitive and specific marker for early detection of renal injury) (21-23) in renal injury. This finding has also been proved in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…This finding has also been proved in the present study. The roles of antioxidant agents such as Tetramethylpyrazine (8), hydroxytyrosol (20), vitamin C (24) and garlic extract (2) have been indicated in several studies to improve nephrotoxicity caused by the use of gentamicin and to reduce the symptoms of the disorder. In our study, we also investigated the role of ferulic acid as an antioxidant agent in improving nephrotoxicity caused by gentamicin.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

Hasanvand¹,

Kharazmkia²,

Mir³

et al. 2018

J Renal Inj Prev

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The most common symptoms of nephrotoxicity include decreased glomerular filtration, increased creatinine, blood urea nitrogen, uric acid, alkaline phosphatase, and electrolyte changes. Ferulic acid is a natural compound with a phenolic group which is found mainly in citrus, rice and coffee. In numerous studies, many roles have been identified for this substance, including anticancer, nephroprotective, hepatoprotective and anti-inflammatory activities.

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Protective effects of hydroxytyrosol on gentamicin induced nephrotoxicity in mice

Cited by 22 publications

References 20 publications

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Protective role of dichloromethane extract of solanum dasyphyllumin in gentamicin induced nephrotoxicity in mice

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

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