Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury &lt;i&gt;via&lt;/i&gt; Activation of eNOS in Rats

Wang, Yanyan; Li, Yanyan; Lin, Li; Yang, Dongli; Zhou, Kun; Li, Yuhong

doi:10.1248/bpb.b18-00212

Cited by 24 publications

(23 citation statements)

References 39 publications

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“…However, current studies on the approach cannot figure out myocardial ischemia. In the traditional Chinese medicine, SF injection has been routinely used for the treatment of cardiac diseases, such as acute myocardial dysfunction and chronic congestive heart failure [ 19 ] , and can protect against ischemia-reperfusion injury [ 7 , 20 , 21 ] , so we hypothesized that SF injection may alleviate the myocardial injury in heart preservation, and this study aimed to evaluate the effect of SF injection on the normothermic beating perfusion preservation of donor hearts. We did observe a protective effect in terms of hemoglobin, anti-apoptotic proteins, and ultrastructural changes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Yin¹,

Feng²,

Mo³

et al. 2020

Braz J Cardiovasc Surg

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Objective To investigate the effect of Shenfu (SF) injection on donor heart preservation. Methods Twelve pigs were randomly divided into SF group (n=6) and control group (n=6). After eight hours of perfusion, the differences in hemoglobin, the expression of Bcl-2 and BAX, and changes in the myocardial ultrastructure were compared to illustrate the effects of SF injection in heart preservation. Results The differences in free hemoglobin between the SF group and the control group were statistically significant ( P =0.001), and there was significant interaction of groups with times ( P =0.019), but the perfusion time may not be associated with the hemoglobin concentration ( P =0.616). According to Western blotting analysis, the expression of Bcl-2 was higher in the SF group than in the control group, while the expression of BAX was not different between the two groups. As to ultrastructural changes, both groups exhibited mitochondrial swelling and myofilament lysis, but the degree of damage in the SF group was smaller. Conclusion Our study suggests that the application of SF injection for heart preservation may protect against cardiomyocytes and erythrocytes apoptosis, and Bcl-2 protein may play a role in these physiological processes.

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Section: Discussionmentioning

confidence: 99%

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Yin¹,

Feng²,

Mo³

et al. 2020

Braz J Cardiovasc Surg

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“…[ 36 , 37 ] TCMI has recently been shown to play an important role in antimyocardial ischemia-reperfusion injury, possibly associated with increased expression of Bcl-2 and decreased expression of Bax and Caspase 3, as well as Akt/eNOS signaling. [ 38 , 39 ]…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of traditional Chinese medicine injections in the treatment of acute myocardial infarction

Zhao

Chen

et al. 2020

Medicine

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Background: As one of the common cardiovascular diseases, acute myocardial infarction (AMI) is characterized by a high mortality rate, frequent complications, and a serious threat to human health and quality of life. Traditional Chinese medicine injection (TCMI) has been used clinically to treat AMI; however, there is no uniform standard for clinical treatment of AMI. The purpose of this study is to evaluate the efficacy and safety of different TCMI by using systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve both 4 Chinese databases and 3 English databases by June 30, 2020. After a series of screening, randomized controlled trials will be included related to TCMI for AMI. Two researchers will use Aggregate Data Drug Information System and STATA 15.0 to analyze the data. Finally, the evidence grade of the results will be evaluated. Results: This study will provide a reliable evidence for the selection of TCMI therapies for AMI. Conclusion: The results of this study will provide references for evaluating the influence of different TCMI therapies for AMI, and provide decision-making references for clinical research. OSF registration number: DOI 10.17605/OSF.IO/FYGBT.

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“…In our meta-analysis, about 53% of studies used Shenfu injection (SFI), which has a positive effect in supplementing Qi and warming Yang. Clinical and experimental studies have shown that SFI could act on multiple organs and prevent ischemia-reperfusion injury [ 7 ], especially for myocardial dysfunction and brain injury [ 20 , 27 ], which may be related to its significant effect on the improvement of energy metabolism, eliminating oxygen free radical, reducing Ca 2+ overload blockage, suppression of the inflammatory reaction, and inhibition of apoptosis [ 14 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, CHM treatment combined with conventional western therapy (combined CHM therapy) has been widely used to treat patients after CPR. A large number of clinical trials [ 7 – 14 ] have proved that the approach of combined CHM therapy could decrease mortality and improve prognosis. This systematic review aims to summarize the current research results on the effectiveness of combined CHM therapy on the risk of mortality and the complication rate in patients after CPR.…”

Section: Introductionmentioning

confidence: 99%

Effect of Combination of Chinese Herbal Medicine versus Western Medicine on Mortality in Patients after Cardiopulmonary Resuscitation: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Guo

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Introduction. Although Chinese herbal medicine (CHM) treatment combined with conventional western therapy has been widely used and reported in many clinical trials in China, there is uncertainty about the efficacy of this combination in the treatment of patients after cardiopulmonary resuscitation (CPR). This systematic review aimed to assess whether the risk of mortality has decreased comparing the combination of CHM treatment with conventional western therapy. Methods. To identify relevant studies, the literature search was conducted in Medline, Embase, the Cochrane Library, CBM, CNKI, VIP, and Wanfang database. We included all randomized controlled trials (RCTs) that compared outcomes of patients after CPR taking combination of CHM treatment with those taking just conventional western therapy. Results. This meta-analysis showed that patients randomly assigned to combined CHM treatment group had a statistically significant 23% reduction in mortality compared with those randomly assigned to conventional western therapy group (RR: 0.77; 95% CI: 0.70–0.84). Conclusions. This meta-analysis provides evidence suggesting that a combined CHM therapy is associated with a decreased risk of mortality compared with conventional western therapy in patients after CPR. Further studies are needed to provide more evidence to prove or refute our conclusion and identify reasons for the reduction of mortality.

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Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury <i>via</i> Activation of eNOS in Rats

Cited by 24 publications

References 39 publications

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Efficacy and safety of traditional Chinese medicine injections in the treatment of acute myocardial infarction

Effect of Combination of Chinese Herbal Medicine versus Western Medicine on Mortality in Patients after Cardiopulmonary Resuscitation: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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