Protective Effects of Various Methanol Extracts of Crude Drugs on Experimental Hepatic Injury Induced by Carbon Tetrachloride in Rats

Kumazawa, Noriko; Ohta, Setsuko; Ishizuka, Osamu; Sakurai, Nobuko; Kamogawa, Asahi; Shinoda, Masato

doi:10.1248/yakushi1947.110.12_950

Cited by 9 publications

(8 citation statements)

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“…According to Cheng and Tsai [27], the mono-oxygenases of Gentianae scabrae radix modulate liver microsomal cytochrome P450. Solamargine purified from Solanum incanum triggers gene expression of human TNF receptor I, which may lead to cell apoptosis [28]; Forsythiae fructus protects against CC14 hepatic injury by inhibition of lipid peroxidation in hepatic microsomes [29]. Antidepressants [30] and vitamin B supplementation [31] have been reported in association with SR.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

Chohan

Taylor

Coffin

et al. 2019

Case Reports in Medicine

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Background. Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, although it has been described by numerous groups. The long-term fate of individuals experiencing an SR is not well described, and the underlying mechanism(s) of SR are unknown.Case Presentation: A 79-year-old Asian female with metastatic HCC taking only valsartan for hypertension had a marked reduction in tumor dimension in the primary tumor and the pulmonary metastases. Serum alpha-fetoprotein (AFP) decreased from 17,833 μg/L to 26 μg/L. Her disease progressed after 71 months, and she died shortly after. In a review of 66 patients with SR reported in the English literature, median survival was 83 months. Median survival in 37 cases that underwent resection after SR was 108 months.Conclusions. The case and a review of the literature illustrate that SR is often durable and associated with an excellent prognosis. Understanding the underlying mechanism of SR may point to novel therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

Chohan

Taylor

Coffin

et al. 2019

Case Reports in Medicine

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“…SHCZF consists of 5 herbal medicines, including Dahuang (Rhei Radix et Rhizoma), Huangbai (Phellodendri Chinensis Cortex), Huangzhizi (Gardeniae Fructus), Chaihu (Bupleuri Radix), and Baizhu (Atractylodis Macrocephalae Rhizome) [12]. Previous studies showed that numerous active components in these medicines exhibited obvious protective effects on liver diseases, such as emodin, demethyleneberberine, polysaccharides, and so on [13,17,18,[38][39][40]. SHCZF exhibited a mitigative effect on ANIT-induced acute IC in rats [41].…”

Section: Discussionmentioning

confidence: 99%

San-Huang-Chai-Zhu Formula Ameliorates Liver Injury in Intrahepatic Cholestasis through Suppressing SIRT1/PGC-1α-Regulated Mitochondrial Oxidative Stress

Liu

Zhang

Shao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Chinese herbal formulae possess promising applications in treating intrahepatic cholestasis. Objective. Our study aims to explore the protective effect of the San-Huang-Chai-Zhu formula (SHCZF) on liver injury in intrahepatic cholestasis (IC) and investigate the underlying mechanism related to mitochondrial oxidative stress. Methods. An IC rat model was established by α-naphthyl isothiocyanate induction. Hepatic histomorphology was observed through hematoxylin and eosin staining. Levels of biochemical indexes of hepatic function and oxidative stress were determined by an enzyme-linked immunosorbent assay. Cell apoptosis in liver tissues was detected by the TUNEL assay. The mRNA expression of mtDNA, SIRT1, and PGC-1α was measured by qRT-PCR, and the protein expression of Bax, Bcl-2, caspase-3, SIRT1, and PGC-1α was determined by Western blotting. Results. SHCZF treatment attenuated liver injury in IC. Levels of hepatic function parameters were decreased after SHCZF administration. In addition, the decreased level of malondialdehyde (MDA) and the increased levels of superoxide dismutase (SOD), glutathione (GSH), and adenosine triphosphate (ATP) in hepatic mitochondria confirmed that SHCZF could attenuate oxidative stress in IC. SHCZF treatment also reduced the apoptosis in the liver tissues of IC rats. Furthermore, SHCZF administration upregulated the expression of mtDNA, SIRT1, and PGC-1α in IC. Conclusions. SHCZF exerts a protective effect on liver injury in IC via alleviating SIRT1/PGC-1α-regulated mitochondrial oxidative stress.

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“…Some of these have been studied. For example, the monooxygenases of Gentianae scabrae radix modulate liver microsomal cytochrome P450 (Kang et al, 1996); solamargine purified from Solanum incanum triggers gene expression of human TNF receptor I which may lead to cell apoptosis (Chiu et al, 1989;Hsu et al, 1996;Lin et al, 1988a); Forsythiae fructus protects against CC14 hepatic injury by inhibition of lipid peroxidation in hepatic microsomes (Kumazawa et al, 1990); gastrointestinal prokinetics of Amomi semen for management of gastrointestinal dyspepsia (Yamazaki et al, 2000); and phenolic compounds from Mesona procumbens are antioxidants (Hung and Yen, 2002). But our understanding of the pharmacological basis for the beneficial effects of these herbal medicines in hepatocellular carcinoma is still limited.…”

Section: Discussionmentioning

confidence: 99%

Regression of Hepatocellular Carcinoma Spontaneous or Herbal Medicine Related?

Cheng

Tsai

2004

Am. J. Chin. Med.

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Hepatocellular carcinoma is one of the most common causes of death from cancer in Taiwan. Treatments for this disease include surgical resection, transcatheter arterial embolization, chemoembolization and systemic chemotherapy. Without treatment, the prognosis of hepatocellular carcinoma is poor, and mortality continues to be significant even in patients with small tumors detected during follow-up. For patients in Taiwan with advanced hepatocellular carcinoma, traditional herbal medicine is frequently used. However, neither the overall prevalence of this therapy nor its efficacy has been studied systematically. Spontaneous regression of cancer, although rare, may occur, but the mechanism leading to regression is still far from understood. Here, we report a case of hepatocellular carcinoma with complete regression after taking herbal medicine. We cannot be certain how significant the herbal preparation was in the regression of the hepatocellular carcinoma, but the regression of the tumor provides us a reason and hope for further research.

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Protective Effects of Various Methanol Extracts of Crude Drugs on Experimental Hepatic Injury Induced by Carbon Tetrachloride in Rats

Cited by 9 publications

References 0 publications

Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

San-Huang-Chai-Zhu Formula Ameliorates Liver Injury in Intrahepatic Cholestasis through Suppressing SIRT1/PGC-1α-Regulated Mitochondrial Oxidative Stress

Regression of Hepatocellular Carcinoma Spontaneous or Herbal Medicine Related?

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