Protective effects of vitamins E, B and C and<scp>l</scp>-carnitine in the prevention of cisplatin-induced ototoxicity in rats

Tokgöz, Sibel Alicura; Vuralkan, Erkan; Sonbay, N D; Çalışkan, Murat; Saka, Cem; Beşaltı, Ömer; Akın, İstemihan

doi:10.1017/s0022215112000382

Cited by 23 publications

(24 citation statements)

References 32 publications

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“…[29] In another study the effects of vitamins E, B, C, and L-carnitine on cisplatin-induced ototoxicity were investigated, and as a result, the researchers observed that these vitamins, and prominently, and especially vitamin E, and L-carnitine had decreased cisplatin-induced ototoxicity. [30] In our previous study where we investigated protective effects of curcumin, and vitamin E in cisplatin-induced ototoxicity, similar to the result of this study, we detected that these antioxidant molecules alleviated cellular apoptosis induced by cisplatin administration. [14,21] Based on these literature information, we can say that curcumin, and vitamin E may prevent increased apoptosis caused by cisplatin-induced testicular toxicity thanks to their antioxidant, free-radical scavenger and similar activities.…”

Section: Bcl-2 Baxsupporting

confidence: 82%

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

Gevrek

Erdemır

2018

Turkish Journal of Urology

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Section: Bcl-2 Baxsupporting

confidence: 82%

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

Gevrek

Erdemır

2018

Turkish Journal of Urology

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“…For example, lecithin could help preserve cochlear mitochondrial function and lessen age-related ABR threshold elevations in rats [32]. Additionally, vitamins B, E, or C or L-carnitine reduced cisplatin-induced ABR threshold elevation and interwave I-IV interval prolongation in rats [33]. Resveratrol might attenuate cisplatin-induced ototoxicity, as shown by hearing threshold values, wave I and IV latencies, and I-IV intervals [34].…”

Section: Discussionmentioning

confidence: 99%

Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice

Chan

Hwang

2017

PLoS ONE

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To our knowledge, the effects of Spirulina platensis water extract (SP) on hearing function have not yet been reported. This study investigated the effects of SP on the function and redox status of the auditory system. Auditory brainstem responses and redox status were compared between two groups of 3-month-old senescence-accelerated prone-8 (SAMP8) mice: the control group was fed a normal diet, and the experimental group was fed a normal diet with oral supplementation of SP for 6 weeks. Compared with the control group, the experimental group had significantly lower hearing thresholds according to auditory brainstem responses measured using click sounds and 8-kHz tone burst sound stimulation at the end of this study. The experimental group had a shorter I-III interval of auditory brainstem responses with 16-kHz tone burst stimulation than the control group that was of borderline significance. Additionally, the experimental group had significantly higher mRNA expression of the superoxide dismutase and catalase genes in the cochlea and brainstem and significantly higher mRNA expression of the glutathione peroxidase gene in the cochlea. Further, the experimental group had significantly lower malondialdehyde levels in the cochlea and brainstem than the control group. However, tumor necrosis factor–α mRNA expression was not significantly different between the control and experimental groups. SP could decrease hearing degeneration in senescence-accelerated prone-8 mice possibly by increasing superoxide dismutase, catalase, and glutathione peroxidase gene expression and decreasing damage from oxidative stress in the cochlea and brainstem.

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“…In animal experiments, vitamins E or C treatment resulted in better auditory sensitivity and less mtDNA deletions with aging [62] and vitamin E or a-lipoic acid attenuated the noise-induced increase of cochlear malondialdehyde [18]. Moreover, a combination of vitamins B1, B2, B6, E, and C was effective in protecting against cisplatin ototoxicity [63] and α-lipoic acid inhibited the kanamycin-induced high expression of phosphorylated p38 and phosphorylated JNK, which mediate cochlear hair cell apoptosis [64]. In studies using auditory cell lines, treatment with D-α-tocopherol or epicatechin reduced the cisplatin-induced increase of ROS and decreased cellular necrosis and apoptosis [65,66].…”

Section: Discussionmentioning

confidence: 93%

The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial

et al. 2019

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Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The objective of the present study was to assess the effects of antioxidant supplementation in tinnitus patients. This is a randomized, double-blind, placebo-controlled clinical trial. Patients (N = 70) were randomly allocated to antioxidant supplementation (N = 35) or to placebo (N = 35) for a total of 3 months. Demographic, anthropometric, clinical, and nutritional data were collected. Serum total antioxidant capacity (TAC), oxidized LDL (oxLDL), and superoxide dismutase (SOD), tinnitus loudness, frequency, and minimum masking level (MML), and scores in Tinnitus Handicap Inventory questionnaire (THI), Tinnitus Functional Index (TFI), and Visual Analogue Scale (VAS) were evaluated at baseline and follow-up. Tinnitus loudness and MML significantly decreased from baseline to post measure (p < 0.001) only in the antioxidant group, the overall change being significantly different between the two groups post-intervention (p < 0.001). THI and VAS decreased only in the antioxidant group. Differences in changes in serum TAC, SOD, and oxLDL post-intervention were insignificant. In conclusion, antioxidant therapy seems to reduce the subjective discomfort and tinnitus intensity in tinnitus patients.

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Protective effects of vitamins E, B and C andl-carnitine in the prevention of cisplatin-induced ototoxicity in rats

Abstract: Vitamins B, E and C and L-carnitine appear to reduce cisplatin-induced ototoxicity in rats. The use of such additional treatments to decrease cisplatin-induced ototoxicity in humans is still under discussion.

Cited by 23 publications

References 32 publications

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice

The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial

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