Protective immunity spectrum induced by immunization with a vaccine from the TBEV strain Sofjin

Chernokhaeva, Liubov L.; Rogova, Yulia V.; Vorovitch, Mikhail F.; Romanova, Lyudmila I.; Kozlovskaya, Liubov I.; Майкова, Г. Б.; Kholodilov, Ivan S.; Karganova, Galina G.

doi:10.1016/j.vaccine.2016.03.041

Cited by 33 publications

(36 citation statements)

References 17 publications

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“…Three mice models were used to evaluate the efficacy of a vaccine against POWV. No protective effect was observed in mice immunized with a TBE vaccine (FSUE Manufacture of Bacterial and Viral Preparations of Chumakov Institute of Poliomyelitis and Viral Encephalitis, Russia) (Chernokhaeva et al., ). However, various levels of protection against POWV in mice and spider monkeys were noted after immunization with the attenuated and wild Langat virus (TP21 E5) vaccine in two studies (Price & Thind, ; Thind & Price, ).…”

Section: Resultsmentioning

confidence: 99%

Powassan virus, a scoping review of the global evidence

Corrin

Greig

Harding

et al. 2018

Zoonoses and Public Health

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Section: Resultsmentioning

confidence: 99%

Powassan virus, a scoping review of the global evidence

Corrin

Greig

Harding

et al. 2018

Zoonoses and Public Health

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“…Due to cross-reactive epitopes, pre-existing vaccine-induced immunity mediates not only protection against homologous, but also heterologous TBEV strains. Among different TBEV subtypes, it was shown that immunization with vaccines based on TBEV-Eu or TBEV-FE elicits cross-subtype reactive antibodies [ 130 , 131 , 132 , 133 , 134 ]. However, studies with various TBEV vaccines showed that cross-protection against heterologous TBEV subtypes is not ensured for any strain [ 134 , 135 ].…”

Section: Immune Response To Tbev Infection and Vaccinationmentioning

confidence: 99%

Tick-Borne Encephalitis Virus: A Quest for Better Vaccines against a Virus on the Rise

et al. 2020

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Tick-borne encephalitis virus (TBEV), a member of the family Flaviviridae, is one of the most important tick-transmitted viruses in Europe and Asia. Being a neurotropic virus, TBEV causes infection of the central nervous system, leading to various (permanent) neurological disorders summarized as tick-borne encephalitis (TBE). The incidence of TBE cases has increased due to the expansion of TBEV and its vectors. Since antiviral treatment is lacking, vaccination against TBEV is the most important protective measure. However, vaccination coverage is relatively low and immunogenicity of the currently available vaccines is limited, which may account for the vaccine failures that are observed. Understanding the TBEV-specific correlates of protection is of pivotal importance for developing novel and improved TBEV vaccines. For affording robust protection against infection and development of TBE, vaccines should induce both humoral and cellular immunity. In this review, the adaptive immunity induced upon TBEV infection and vaccination as well as novel approaches to produce improved TBEV vaccines are discussed.

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“…e PRNT50 analysis was conducted using the Sofjin strain of TBEV (GenBank KC806252) and pig embryo kidney cells (PEK) as previously described [9].…”

Section: % Plaque Reduction Neutralization Test (Prnt50)mentioning

confidence: 99%

“…e primary vaccination course for this vaccine consists of only two injections within a 1-to 7-month interval. According to the results of our previous study using an animal model, this vaccine provides a wide range of protective immunity against all subtypes of TBEV [9]. However, the domestic commercial TBE vaccine intended for use in young children (aged 1 to 3 years) was not available in Russia until 2012, and imported vaccines based on the Eur strains of TBEV were used for childhood immunization.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Immunogenicity and Safety of Two Pediatric TBE Vaccines Based on the Far Eastern and European Virus Subtypes

Vorovitch

Майкова

Chernokhaeva

et al. 2019

Advances in Virology

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Up to 10,000 cases of tick-borne encephalitis are registered annually, 20% of which occur in children under 17 years of age. A comparison of the immunogenicity and safety between a new pediatric Tick-E-Vac vaccine based on the TBEV strain Sofjin and FSME-IMMUN Junior vaccine was performed in the Sverdlovsk region. The vaccine strains differ from strains of the Siberian subtype of TBEV that dominates in the region. The study was performed on 163 children aged 1 to 15, who received one of the vaccines according to either a conventional or rapid vaccination schedule. Immunogenicity was assessed based on the seroprotection rates and titers of virus-neutralizing antibodies. There were no significant differences in either the immunogenicity or reactogenicity of the pediatric vaccines based on strains of the Far Eastern or European subtypes of TBEV. Under both vaccination schedules, 30 days after the second injection, seroprotection rates were 100% for Tick-E-Vac and greater than 95% for FSME-IMMUN Junior, while the geometric mean titer of TBEV-neutralizing antibodies was at least 2,4 log10 (1 : 250) for either vaccine. Fourteen days after the second injection according to the rapid schedule, seroprotection rates were significantly lower, ranging from 50% to 63% regardless of the vaccine used. The observed adverse reactions were mild or moderate for both vaccines under both vaccination schedules, with total adverse event rates of less than 25%. Reactogenicity was not associated with the gender or age of the recipients. There were no statistically significant differences in the incidence of adverse reactions between the group of subjects who were baseline seronegative or seropositive. However, 14 days after the second vaccine injection according to the rapid schedule, a statistically significant difference in nAbs titers was identified between groups of children with and without reported reactions.

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Protective immunity spectrum induced by immunization with a vaccine from the TBEV strain Sofjin

Cited by 33 publications

References 17 publications

Powassan virus, a scoping review of the global evidence

Powassan virus, a scoping review of the global evidence

Tick-Borne Encephalitis Virus: A Quest for Better Vaccines against a Virus on the Rise

Comparison of the Immunogenicity and Safety of Two Pediatric TBE Vaccines Based on the Far Eastern and European Virus Subtypes

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