Protein Abundance Variation

Hernández, Greco; Tettweiler, Gritta

doi:10.1002/3527600906.mcb.201100039

Cited by 3 publications

(3 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Translation plays a crucial role in the composition and quantity of the cellular proteome in all forms of life and diseases ( Tian et al, 2004 ; Vogel et al, 2010 ; Schwanhausser et al, 2011 ; Hernández and Tettweiler, 2012 ; Wang et al, 2013 ). Thus, dysregulated translation is a cause of cancer development.…”

Section: Dysregulation Of Translation Initiation As a Key Cause Of Ca...mentioning

confidence: 99%

The dark side of mRNA translation and the translation machinery in glioblastoma

Montiel-Dávalos

Ayala²,

Hernández³

2023

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

Among the different types of cancer affecting the central nervous system (CNS), glioblastoma (GB) is classified by the World Health Organization (WHO) as the most common and aggressive CNS cancer in adults. GB incidence is more frequent among persons aged 45–55 years old. GB treatments are based on tumor resection, radiation, and chemotherapies. The current development of novel molecular biomarkers (MB) has led to a more accurate prediction of GB progression. Moreover, clinical, epidemiological, and experimental studies have established genetic variants consistently associated with the risk of suffering GB. However, despite the advances in these fields, the survival expectancy of GB patients is still shorter than 2 years. Thus, fundamental processes inducing tumor onset and progression remain to be elucidated. In recent years, mRNA translation has been in the spotlight, as its dysregulation is emerging as a key cause of GB. In particular, the initiation phase of translation is most involved in this process. Among the crucial events, the machinery performing this phase undergoes a reconfiguration under the hypoxic conditions in the tumor microenvironment. In addition, ribosomal proteins (RPs) have been reported to play translation-independent roles in GB development. This review focuses on the research elucidating the tight relationship between translation initiation, the translation machinery, and GB. We also summarize the state-of-the-art drugs targeting the translation machinery to improve patients’ survival. Overall, the recent advances in this field are shedding new light on the dark side of translation in GB.

show abstract

Section: Dysregulation Of Translation Initiation As a Key Cause Of Ca...mentioning

confidence: 99%

The dark side of mRNA translation and the translation machinery in glioblastoma

Montiel-Dávalos

Ayala²,

Hernández³

2023

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Translation is the most dynamic process to regulate the composition and quantity of a cell´s proteome. Translational control enables rapid changes in the translatability of mRNAs in response to environmental, physiological, and developmental clues (1)(2)(3). Part of this regulation occurs in large, membrane-less cumuli of assembled proteins and non-translating mRNAs termed mRNP granules or cytoplasmic foci.…”

Section: Introductionmentioning

confidence: 99%

Distinct domains of Me31B interact with different eIF4E isoforms in the male germ line ofDrosophila melanogaster

Layana

Corujo

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Eukaryotic translation initiation factor 4E (eIF4E) is a key factor involved in different aspects of mRNA metabolism. Drosophila melanogaster genome encodes eight eIF4E isoforms, and the canonical isoform eIF4E-1 is a ubiquitous protein that plays a key role in mRNA translation. eIF4E-3 is specifically expressed in testis and controls translation during spermatogenesis. In eukaryotic cells, translational control and mRNA decay is highly regulated in different cytoplasmic ribonucleoprotein foci, which include the processing bodies (PBs). In this study, we show that Drosophila eIF4E-1 and eIF4E-3 occur in PBs where might play a role in mRNA storage and translational repression. We also demonstrate that the DEAD-box RNA helicase Me31B, a component of PBs, physically interacts with eIF4E-1 and eIF4E-3 both in the yeast two-hybrid system and FRET in Drosophila S2 cells. Moreover, truncated and point mutated Me31B proteins indicate that the binding sites of Me31B for eIF4E-1 and eIF4E-3 are located in different domains. Residues Y401-L407 (at the carboxy-terminal) are essential for interaction with eIF4E-1, whereas residues F63-L70 (at the amino-terminal) are critical for interaction with eIF4E-3. Thus, Me31B represents a novel type of eIF4E-interacting protein. Our observations suggest that Me31B might recognize different eIF4E isoforms in different tissues, which could be the key to silencing specific messengers. They provide further evidence that alternative forms of eIF4E and their interactions with various partners add complexity to the control of gene expression in eukaryotes.

show abstract

“…Cancer often results from glitching the interconnection between different metabolic networks and molecular processes (1), such as translation and autophagy. Translation is a fundamental process for all forms of life because it plays a central role in gene expression, and translational control critically contributes to the composition and quantity of a cell's proteome (2)(3)(4)(5). Recently, dysregulation of translational control has been recognized as a cause of malfunctioning of other key cellular processes, which may lead to the onset and development of different types of cancer (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Autophagy Regulation by the Translation Machinery and Its Implications in Cancer

et al. 2020

Self Cite

View full text Add to dashboard Cite

Various metabolic pathways and molecular processes in the cell act intertwined, and dysregulating the interplay between some of them may lead to cancer. It is only recently that defects in the translation process, i.e., the synthesis of proteins by the ribosome using a messenger (m)RNA as a template and translation factors, have begun to gain strong attention as a cause of autophagy dysregulation with effects in different maladies, including cancer. Autophagy is an evolutionarily conserved catabolic process that degrades cytoplasmic elements in lysosomes. It maintains cellular homeostasis and preserves cell viability under various stress conditions, which is crucial for all eukaryotic cells. In this review, we discuss recent advances shedding light on the crosstalk between the translation and the autophagy machineries and its impact on tumorigenesis. We also summarize how this interaction is being the target for novel therapies to treat cancer.

show abstract

Protein Abundance Variation

Cited by 3 publications

References 133 publications

The dark side of mRNA translation and the translation machinery in glioblastoma

The dark side of mRNA translation and the translation machinery in glioblastoma

Distinct domains of Me31B interact with different eIF4E isoforms in the male germ line ofDrosophila melanogaster

Autophagy Regulation by the Translation Machinery and Its Implications in Cancer

Contact Info

Product

Resources

About