2010
DOI: 10.1016/j.actbio.2010.01.015
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Protein adhesion and cell response on atmospheric pressure dielectric barrier discharge-modified polymer surfaces

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Cited by 62 publications
(41 citation statements)
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“…The reactive oxygen groups slowly decompose to form more stable oxidative groups such as hydroxyls. A detailed explanation of the oxidation of PMMA observed by XPS analysis after DBD modification has been previously reported by us [44]. In the case of DLC-coated samples, they had less oxygen and hydrocarbon groups.…”
Section: Resultssupporting
confidence: 54%
“…The reactive oxygen groups slowly decompose to form more stable oxidative groups such as hydroxyls. A detailed explanation of the oxidation of PMMA observed by XPS analysis after DBD modification has been previously reported by us [44]. In the case of DLC-coated samples, they had less oxygen and hydrocarbon groups.…”
Section: Resultssupporting
confidence: 54%
“…Since cells require the presence of specific regions of the proteins to adhere to the surface this change in conformation can lead to the reduction in cell attachment. Whereas on more hydrophilic surfaces it is more likely that the proteins will maintain their natural 3D conformation when they adsorb onto the surface and thus maintain the necessary binding sites for cell attachment . It was hypothesized that the oxygen incorporation into treated surfaces resulting in an increase in hydrophilicity and would encourage serum protein adsorption with a conformation promoting cellular attachment, although it is well recognized that there is not a specific contact angle at which the optimal protein interactions occur.…”
Section: Resultsmentioning
confidence: 99%
“…It is widely known that material properties such as the surface chemistry, wettability and roughness can affect the cellular response [74][75][76][77]. This could be achieved by modifying a surface to enable attachment of a LEC monolayer that maintains an epithelial phenotype.…”
Section: Cornea and Conjunctivamentioning
confidence: 99%