Protein adsorption on heterogeneous surfaces

Abstract

Controlled surface adsorption of fd filamentous phage by tuning of the pH and the functionalization of the surface J. Appl. Phys. 109, 064701 (2011); 10.1063/1.3549113 Effect of surface adsorbed proteins on the photoluminescence of nanodiamond A SPR and AFM study of the effect of surface heterogeneity on adsorption of proteins

Adsorption of bovine serum albumin on silicon dioxide nanoparticles: Impact of pH on nanoparticle–protein interactions

“…37 Aggarwal et al conducted a study on pure silica and zirconia nanoparticle surfaces and a mixture of nanoparticle surfaces and found that the composite surface better retains the native protein structure upon adsorption. 38 ATR-FTIR spectroscopy is particularly useful for realtime in situ analysis of protein adsorption on metal oxide nanoparticles. 30,[39][40][41][42] This technique probes the interfacial region between a nanoparticle thin film and the protein due to the evanescent wave produced from each reflection as well as the transparency of the metal oxide nanoparticle layer in the infrared region.…”

Introduction to medical materials and devices

“…That the simple model averaging the various electron donating and accepting components is inadequate can already be seen by the behaviour of the abundant protein serum albumin, which according to the single-substance surface tension data should be repelled from pure silica, whereas it is a well-known experimental fact that it is strongly adsorbed. Similarly theoretically unexpected behaviour is observed with adsorption on heterogeneous materials (Aggarwal et al ., 2009 ). Furthermore, it must be borne in mind that the native conformation of a protein is principally due to intramolecular hydrogen bonds between the backbone peptide bonds.…”

Biocompatibility of implantable systems

“…One might guess that these equations are only of very limited utility when the heterogeneity of the artifi cial surface is commensurate with that of the biological entity. Aggarwal et al ( 2009 ) recently showed experimentally that striking departures from the mean-fi eld predictions are to be observed in such cases. This constitutes a promising research area -both theoretical and experimental -of great interest for developing more biocompatible surfaces.…”