Protein corona between nanoparticles and bacterial proteins in activated sludge: Characterization and effect on nanoparticle aggregation

Zhang, Peng; Xu, Xin; Chen, You‐Peng; Xiao, Meng-Qian; Feng, Bo; Tian, Kaixun; Chen, Yuehui; Dai, Yong

doi:10.1016/j.biortech.2017.11.008

Cited by 22 publications

(9 citation statements)

References 40 publications

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“…Although beyond the scope of this piece, recent reviews on environmental coronas provide detailed insight into ENM transformations upon interaction with NOM and DOM. 4,37 Bio-transformations of ENMs in soil, 38 wastewater, 6,39 and aquatic environments 10,[40][41][42][43] impact subsequent protein corona formation, and are essential considerations in assessing downstream (nano)ecotoxicology and nanosafety.…”

Section: Nanomaterials and Protein Transformationsmentioning

confidence: 99%

Environmental dimensions of the protein corona

et al. 2021

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The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical, and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily on biomedical applications and human toxicity. The relevance of the environmental dimensions of the protein corona are still emerging. Often referred to as the eco-corona, a biomolecular coating forms upon nanomaterials as they enter the environment and may include proteins, as well as a diverse array of other biomolecules such as metabolites from cellular activity and/or natural organic matter. Proteins remain central in studies of eco-coronas because of the ease of monitoring and structurally characterising proteins, as well as their crucial role in receptor engagement and signaling. The proteins within the eco-corona are optimal targets to establish the biophysicochemical principles of corona formation and transformation, as well as downstream impacts on nanomaterial uptake, distribution, and impacts on the environment. Moreover, proteins appear to impart a biological identity leading to cellular or organismal recognition of nanomaterials, a unique characteristic in comparison to natural organic matter. We contrast insights into protein corona formation from clinical samples with those in environmentally relevant systems. Principles specific to the environment are also explored to gain insights into dynamics of interaction with / exchange by other biomolecules, including changes during trophic transfer and ecotoxicity. With many challenges remaining, we also highlight key opportunities for method development and impactful systems on which to focus the next phase of eco-corona studies. By interrogating these environmental dimensions of the protein corona, we offer a perspective on how mechanistic insights into protein coronas in the environment can lead to more sustainable, environmentally safe nanomaterials, as well as enhance the efficacy of nanomaterials used in remediation and in the agri-sector.

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Section: Nanomaterials and Protein Transformationsmentioning

confidence: 99%

Environmental dimensions of the protein corona

et al. 2021

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“…The aggregation is thought to occur through click cycloaddition and the size is increased, limiting flow back to tumor vessels, with good retention 31 . Still, there are concerns for the protein corona generated on the surface of the nanoparticles when administered in vivo , which might influence nanoparticle aggregation 32 and have an effect on the final application of this strategy.…”

Section: Emerging Strategies For Drug Deliverymentioning

confidence: 99%

Recent progress in drug delivery

Wang

et al. 2019

Acta Pharmaceutica Sinica B

615

272

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Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015–2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.

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“…Most of them are of interest for research because they are being developed for a variety of diagnostic and therapeutic applications. 14,60,[112][113][114][115][116][117][118][119] These can be polystyrene (PS) with and without surface modications, polyethylene glycol (PEG), polylactide-derivatives (PLGA), resins, crosslinked cellulose, carbon beads or polylactic acid (PLA). The same holds true for the separately listed group of chitosan particles.…”

Section: Particles Used For Corona Studiesmentioning

confidence: 99%