Protein Delivery from Nondegradable Polymer Matrices

Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study

“…Release by diffusion, particularly of watersoluble antibiotics, is non-linear, and often extremely rapid, achieving 90% release within hours or few days [21][22][23][24]. This rate of release is not suitable for effective antibiotic therapy, which requires several lifecycles of the pathogen to obtain eradication.…”

The use of lipid microtubes as a novel slow‐release delivery system for laryngeal injection

“…The vehicle and its fabrication process must be capable of protecting the encapsulated substance and maintaining its bioactivity. Many existing vehicles rely on fabrication processes requiring heat, harsh organic solvents, and other exposures with a strong potential to damage encapsulated substances 7, 8. Fabrication of microtubes theoretically avoids these risks, and recent studies by Lee et al13 found that microtube loaded substances demonstrate sustained biological activity up to 6 weeks after the injection.…”

“…They have a high loading efficiency and efficient release kinetics 7–9. In contrast to many polymer‐based systems whereby therapeutic agents are exposed to heat and organic solvents such as dichloromethane or methylene chloride, lipid‐based microtubes are advantageous in that the loading phase involves hydration alone and avoids the potentially harmful effects of such harsh organic solvents 7, 8. They can encapsulate a wide variety of substances including steroids, peptides, and proteins and are felt capable of maintaining the biological efficacy of encapsulated substances for up to 6 weeks.…”

Controlled Delivery of Peptides and Proteins

“…Silicone elastomer small tubes were first used some 35 years ago to provide controlled release of compounds [65], after which the contraceptive delivery system called Norplant was developed. Silicone elastomer small tubes were first used some 35 years ago to provide controlled release of compounds [65], after which the contraceptive delivery system called Norplant was developed.…”

“…Silicone elastomer small tubes were first used some 35 years ago to provide controlled release of compounds [65], after which the contraceptive delivery system called Norplant was developed. Similarly, poly(ethylene-co-vinyl acetate) (EVAC) was used to prepare an implant for contraception (Progestasert ), eye diseases (Ocusert ), hormone replacement therapy (Estraderm ) and nitroglycerine administration (Transderm Nitro ) [65]. The Norplant system consists of six very small matchstick-sized capsules (made of silastic tubing) that are placed just under the skin of the upper arm [66].…”