1995
DOI: 10.1006/jmbi.1995.0396
|View full text |Cite
|
Sign up to set email alerts
|

Protein Flexibility and Adaptability Seen in 25 Crystal Forms of T4 Lysozyme

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

18
227
1

Year Published

1996
1996
2009
2009

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 202 publications
(246 citation statements)
references
References 0 publications
18
227
1
Order By: Relevance
“…Phe 67 has been identified as one of the sidechains that changes conformation in association with interdomain, hinge-bending, motion (Zhang et al, 1995). In the present context, however, the Phe 67 + Ala substitution did not cause a significant hingebending displacement.…”
Section: Phenylalanine 67 To Alaninecontrasting
confidence: 55%
“…Phe 67 has been identified as one of the sidechains that changes conformation in association with interdomain, hinge-bending, motion (Zhang et al, 1995). In the present context, however, the Phe 67 + Ala substitution did not cause a significant hingebending displacement.…”
Section: Phenylalanine 67 To Alaninecontrasting
confidence: 55%
“…The accumulation of these minor local effects over large segments of the chain can result in signi®cant displacement of atoms that belong to residues distant in sequence. In fact, the extent of local deviation of structure for most variants is generally no greater than that seen in comparing structures of the same protein solved in different space groups (Zhang et al, 1995).…”
Section: Constructing a Backbone Potentialmentioning
confidence: 88%
“…9 The outlier marked number 1 in Figure 7 is of particular interest. This structure, 179L, is one of many T4 lysozyme mutants published by Matthews et al 10 All of the many hundreds of similar T4 lysozyme structures from Matthews et al have packing scores that are at least average given their resolution, and most are well above average. Comparison of 179L with 177L, which are the same mutation and the same crystal space group, revealed that the placement of secondary structure elements in 179L is stretched along two axes.…”
Section: Packing Analysis Of Structures In the Pdbmentioning
confidence: 99%