2005
DOI: 10.1074/jbc.m500787200
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Protein Import, Replication, and Inheritance of a Vestigial Mitochondrion

Abstract: Mitochondrial remnant organelles (mitosomes) that exist in a range of "amitochondrial" eukaryotic organisms represent ideal models for the study of mitochondrial evolution and for the establishment of the minimal set of proteins required for the biogenesis of an endosymbiosis-derived organelle. Giardia intestinalis, often described as the earliest branching eukaryote, contains double membrane-bounded structures involved in ironsulfur cluster biosynthesis, an essential function of mitochondria. Here we present … Show more

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Cited by 101 publications
(106 citation statements)
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“…Similarly, the mitochondrial targeting signal from Trypanosoma cruzi was also shown to be interchangeable with that of E. histolytica (303,316). While import of ferredoxin and IscU, a scaffolding protein for iron-sulfur biosynthesis, relies on the amino-terminal signal, the targeting of other mitosomal proteins (e.g., the catalytic component of iron-sulfur cluster biosynthesis IscS, Cpn60, and mitochondrial Hsp70) into the mitosome does not require this presequence in G. intestinalis (258). The underlying mechanisms of mitosome import of the latter proteins are not clear, but they likely possess cryptic internal signals, as demonstrated in the ADP-ATP carrier protein localized in the hydrogenosome of T. vaginalis (74) and other proteins found in the inner membrane of mitochondria (248).…”
Section: Three Major Iron-sulfur Proteins That Play An Essential Rolementioning
confidence: 99%
“…Similarly, the mitochondrial targeting signal from Trypanosoma cruzi was also shown to be interchangeable with that of E. histolytica (303,316). While import of ferredoxin and IscU, a scaffolding protein for iron-sulfur biosynthesis, relies on the amino-terminal signal, the targeting of other mitosomal proteins (e.g., the catalytic component of iron-sulfur cluster biosynthesis IscS, Cpn60, and mitochondrial Hsp70) into the mitosome does not require this presequence in G. intestinalis (258). The underlying mechanisms of mitosome import of the latter proteins are not clear, but they likely possess cryptic internal signals, as demonstrated in the ADP-ATP carrier protein localized in the hydrogenosome of T. vaginalis (74) and other proteins found in the inner membrane of mitochondria (248).…”
Section: Three Major Iron-sulfur Proteins That Play An Essential Rolementioning
confidence: 99%
“…Import pathways are also conserved between Giardia mitosomes and mitochondria (Dolezal et al 2005;Regoes et al 2005). For example, the N-terminal presequence from the Giardia mitosomal ferredoxin is both necessary and sufficient to guide green fluorescent protein into mammalian mitochondria (Regoes et al 2005).…”
Section: The Demise Of Archezoamentioning
confidence: 99%
“…For example, the N-terminal presequence from the Giardia mitosomal ferredoxin is both necessary and sufficient to guide green fluorescent protein into mammalian mitochondria (Regoes et al 2005). Study of the microsporidian mitosome has lagged behind study of other mitochondrial homologues, because Microsporidia are obligate intracellular parasites, and there are no homologous transfection methods like those established for Entamoeba, Giardia and Trichomonas.…”
Section: The Demise Of Archezoamentioning
confidence: 99%
“…(Heterocontophyta) (23), and a single mitochondrion of Cryptosporidium (Apicomplexa) (1,17,37) may also be implicated in the core carbon and energy metabolism of parasites. The metabolic role of small, abundant (10 to 150 organelles per cell), double-membrane-bounded organelles called mitosomes that were found in Entamoeba histolytica (Amoebozoa) (26), Giardia lamblia (Metamonada) (18), microsporidium species Trachipleistophora hominis (36), and Encephalitozoon cuniculi (27,34) is uncertain. Because these parasites lack any ATPgenerating enzymes of mitochondrial origin, their mitosomes appeared not to be involved in energy metabolism (10).…”
mentioning
confidence: 99%