Abstract:Rather than pathogenic variants in single genes, the likely genetic architecture of complex diseases is that subgroups of patients share variants in genes in specific networks and pathways sufficient to give rise to a shared phenotype. We combined high throughput sequencing with advanced bioinformatic approaches to identify subgroups of patients with shared networks and pathways associated with preterm birth (PTB). We previously identified genes, gene sets and haplotype blocks that were highly associated with … Show more
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