Protein Micropatterns: Multiphoton 3D Microprinting of Protein Micropatterns with Spatially Controlled Heterogeneity – A Platform for Single Cell Matrix Niche Studies (Adv. Biosys. 8/2018)

Abstract

A cell niche is a complex microenvironment that cells are exposed to in tissues. In article number https://doi.org/10.1002/adbi.201800053, Barbara Pui Chan and co‐workers use multiphoton micro‐printing technology to create protein micro‐patterns with independently and spatially controlled matrix and mechanical properties. Human mesenchymal stem cells cultured on a protein micro‐niche spread towards selective protein islands with different extracellular matrices. This platform contributes to highthroughput screening of cell niche factors for biomimetic scaffold design.