Protein nanogels with enhanced pH-responsive dynamics triggered by remote NIR for systemic protein delivery and programmable controlled release

Zhang, Xican; Zhou, Pan; Zhuo, Shijie; Zhang, Feng; Yu, Junyu; Liu, Xiaowen

doi:10.1016/j.ijpharm.2021.120833

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…As example, the cytokine interferon 𝛼 (IFN-𝛼) was loaded in cyclodextrin (CD)-based NGs by Zhang and co-workers. [84] They recently developed a pH-responsive NG that was formed by hostguest interactions between a 𝛽-CD functionalized 6-arm PEG and a similar star-shaped PEG that was end functionalized with a near-infrared IR825 dye. These NGs were designed for the delivery of IFN-𝛼 (Figure 8).…”

Section: Physical Entrapmentmentioning

confidence: 99%

Rational Design and Development of Polymeric Nanogels as Protein Carriers

López‐Iglesias

Klinger

2023

Macromolecular Bioscience

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Proteins have gained significant attention as potential therapeutic agents owing to their high specificity and reduced toxicity. Nevertheless, their clinical utility is hindered by inherent challenges associated with stability during storage and after in vivo administration. To overcome these limitations, polymeric nanogels (NGs) have emerged as promising carriers. These colloidal systems are capable of efficient encapsulation and stabilization of protein cargoes while improving their bioavailability and targeted delivery. The design of such delivery systems requires a comprehensive understanding of how the synthesis and formulation processes affect the final performance of the protein. This review highlights critical aspects involved in the development of NGs for protein delivery, with specific emphasis on loading strategies and evaluation techniques. For example, factors influencing loading efficiency and release kinetics are discussed, along with strategies to optimize protein encapsulation through protein‐carrier interactions to achieve the desired therapeutic outcomes. The discussion is based on recent literature examples and aims to provide valuable insights for researchers working towards the advancement of protein‐based therapeutics.This article is protected by copyright. All rights reserved

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Section: Physical Entrapmentmentioning

confidence: 99%

Rational Design and Development of Polymeric Nanogels as Protein Carriers

López‐Iglesias

Klinger

2023

Macromolecular Bioscience

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“…A previous study reported that 6-arm PEGylated crystalline β-CD could be assembled with IR825 dye to form nanoparticles, through host-guest interaction. It was characterized by an excellent ability to encapsulate proteins (INFα) 104 . Importantly, IR825 in the nanoparticles could promote protein release following near-infrared illumination, which could be used to enhance cancer treatment.…”

Section: Co-transport Of Protein and Othersmentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

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Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: Drug delivery and beyond

Topuz

Uyar²

2022

Carbohydrate Polymers

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Protein nanogels with enhanced pH-responsive dynamics triggered by remote NIR for systemic protein delivery and programmable controlled release

Cited by 5 publications

References 47 publications

Rational Design and Development of Polymeric Nanogels as Protein Carriers

Rational Design and Development of Polymeric Nanogels as Protein Carriers

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: Drug delivery and beyond

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