Protein Peroxidation Processes in Bovine Retained and Not‐retained Placenta

Kankofer, Marta

doi:10.1046/j.1439-0442.2001.00352.x

Cited by 16 publications

(12 citation statements)

References 11 publications

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“…The concentrations of the thiol groups showed the opposite relationship. The levels of tryptophan were lower in retained placenta than in control animals (Kankofer 2001b). The level of 8OH‐dG, the parameter indicating the intensity of DNA oxidative damage, was higher in retained than not retained placenta of cows undergoing caesarian section, but lower in retained placenta of spontaneously delivering animals (Kankofer and Schmerold, submitted).…”

Section: Peroxidative Processes and Placental Retentionmentioning

confidence: 75%

Placental Release/Retention in Cows and its Relation to Peroxidative Damage of Macromolecules

Kankofer¹

2002

Reprod Domestic Animals

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The disturbances in metabolic pathways reflected in clinical symptoms of illnesses may be connected, among others, with the imbalance between production and neutralization of reactive oxygen species. One of such illnesses may be the retention of fetal membranes in cows. The levels of reactive oxygen species can be measured directly or estimated indirectly by the determination of enzymatic and non-enzymatic antioxidative defence systems. The determination of parameters indicating the intensity of peroxidative processes of lipids, proteins and nucleic acids caused by reactive oxygen species is also useful. This review examined the available literature regarding peroxidative processes of lipids, proteins and nucleic acids caused by reactive oxygen species as well as parameters indicating its intensity. All information relates the importance of proper and improper placental release in cows.

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Section: Peroxidative Processes and Placental Retentionmentioning

confidence: 75%

Placental Release/Retention in Cows and its Relation to Peroxidative Damage of Macromolecules

Kankofer¹

2002

Reprod Domestic Animals

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“…Tryptophan is oxidised to formylokinurenine. As the result of the recombination of tyrosine radicals, bityrosine bridges are created [29].…”

Section: Discussionmentioning

confidence: 99%

Influence of two different feeding strategies in the dry period on dry matter intake and plasma protein peroxidative and antioxidative profile during dry period and early lactation

Gundelach

Streuff²,

Franczyk

et al. 2020

BMC Vet Res

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Background: Dairy cows undergo dramatic changes in endocrine and metabolic status around parturition and in early lactation. Meeting the nutritional requirements of transition dairy cows is important for animal health, production and animal wellbeing. Dry cow feeding and managing play an essential role in this. The changes in metabolism of periparturient cows also lead to a rise in the production of oxidising agents, leading to oxidative stress. The relationship between dry cow diet composition and oxidative stress has received little research attention so far. In the present study, the influence of two different dry cow feedings (single diet with medium energy content over the whole dry period versus traditional two-phase diet with a low-energy "far-off" ration and a high energy "close-up" ration) on dry matter intake, energy intake and plasma protein peroxidative and antioxidative profile was investigated. Results: The examined parameters revealed a dynamic profile within the experimental period. Dry matter intake (DMI) did not differ between groups. However, there was a time and a group x time interaction effect: Group 1 ("one-phase") had a very constant DMI with a slow and even decrease until calving. In Group 2 ("two-phase"), an initial increase in DMI two weeks antepartum (a.p.) was followed by a sharp drop at week 1 a.p.. The highest total antioxidant capacity and sulfhydryl residue concentration was noted at partus. In contrast, concentration of formylokinurenine and bityrosine bridges as representatives of protein peroxidation were lowest at parturition. The time course of formylokinurenine and bityrosine bridges showed parallels to the DMI. The contents of sulfhydryl groups, formylokinurenine and total antixoxidant capacity did not differ between groups. In contrast, concentration of bityrosine bridges was always higher in Group 2 compared with Group 1 and these differences were statistically significant at week 3 a.p., week 2 a.p., week 1 a.p. and at parturition. Conclusion: The results of our study suggest time-related changes of pro-and antioxidative plasma parameters. Different dry cow feeding affected antepartal DMI. Furthermore, DMI and diet compositions seemed to have an influence on plasma protein peroxidative profile and activity of antioxidative defence.

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“…This peroxidative damage may lead to the modification of amino acid residues, aggregation or fragmentation of protein molecules, altered conformation and loss of the biological activity of proteins (Beal, ; Davis, ; Stadtman & Levine, ). Consequently, the determination of bityrosine, formylokinurenine and SH‐groups can be used as marker of protein peroxidation (Halliwell & Whiteman, ; Kankofer, ; Stadtman & Levine, ).…”

Section: Introductionmentioning

confidence: 99%

Total antioxidant capacity and protein peroxidation intensity in seminal plasma of infertile and fertile dogs

Domosławska

Zduńczyk

Franczyk

et al. 2018

Reprod Domestic Animals

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The aim of this study was to evaluate the total antioxidant capacity and protein peroxidation intensity in seminal plasma of infertile and fertile dogs. The study was conducted on 10 infertile and 10 fertile dogs of various breeds. Infertility was defined as conception failure at least three matings with different bitches. Semen was collected by manual manipulation. The sperm concentration and motility parameters were evaluated using CASA Hamilton Thorne, Vers. IVOS 12.3. The morphology of spermatozoa and the percentage of live and dead sperm cells were assessed microscopically, total antioxidant capacity and the content of SH-groups in seminal plasma were determined spectrophotometrically, the contents of protein peroxidation markers in seminal plasma, bityrosine and formylokinurenine, were determined using spectrofluorimetric methods. Sperm concentration and total sperm count were significantly (p < 0.05) lower in infertile dogs than in fertile dogs (99.92 ± 3 0.05 × 10 /ml vs. 282.07 ± 48.27 × 10 /ml; 214.19 ± 114.74 × 10 vs. 747.57 ± 210.94 × 10 , respectively). The percentage of spermatozoa with normal morphology and the most determined motility parameters differed significantly (p < 0.05) between both groups. The mean values of total antioxidant capacity in the seminal plasma were significantly (p < 0.05) lower (19.95 ± 20.94 vs. 25.66 ± 23.18 µmol/g protein), whereas the mean contents of bityrosine and formylokinurenine in seminal plasma were significantly (p < 0.05) higher in infertile dogs than in fertile dogs (3.71 ± 4.83 µg/mg protein vs. 1.55 ± 2.00 µg/mg protein and 0.37 ± 0.45 µg/mg protein vs. 0.14 ± 0.08 µg/mg protein, respectively). In conclusion, the obtained results suggest that the poor semen quality and infertility in dogs could be associated with lowered total antioxidant capacity and increased protein peroxidation in seminal plasma as a consequence of oxidative stress.

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Protein Peroxidation Processes in Bovine Retained and Not‐retained Placenta

Cited by 16 publications

References 11 publications

Placental Release/Retention in Cows and its Relation to Peroxidative Damage of Macromolecules

Placental Release/Retention in Cows and its Relation to Peroxidative Damage of Macromolecules

Influence of two different feeding strategies in the dry period on dry matter intake and plasma protein peroxidative and antioxidative profile during dry period and early lactation

Total antioxidant capacity and protein peroxidation intensity in seminal plasma of infertile and fertile dogs

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