Protein quality control modulates the metabolic conservation in antibiotic tolerantCampylobacter jejuni
Jinsong Feng,
Shenmiao Li,
Yaxi Hu
et al.
Abstract:Antibiotic tolerance in bacteria emerges as a phenotypic variant known as persisters and has been implicated in recurrent bacterial infections. This tolerance manifests as suppressed metabolism. We demonstrate thatCampylobacter jejunireadily forms persisters in response to both ampicillin and ciprofloxacin. Persisters induced by these two antibiotics with different mechanisms of actions experience consistent metabolic reprogramming, characterized by suppressed respiration and energy metabolism while conserving… Show more
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