Protein structure determination as a powerful tool for the sustainable development of agriculture field (and its potential relevance in Indonesia)

Abstract

Traditional agricultural practices, such as classical plant breeding and pest management, have been utilized for many years to increase crop yield and improve its properties. However, more effective and sustainable practices are needed to meet the increasing global demands for agricultural-based products. In the past decades, DNA recombinant technology, and protein structure determination have been employed as a tool for the development of the agricultural field. Protein structure determination enables us to understand the structure-function relationship of a given protein, such as plant hormone, receptor, or growth regulators, thus introducing modifications to improve the properties of the crop. This review introduces the latest development of protein structure determination techniques ranging from X-ray crystallography, protein NMR, and cryo-electron microscopy. Notable examples of how these techniques can be utilized as a powerful tool for the sustainable development of the agricultural field, including their potential relevance in Indonesia, are introduced.

Petascale Homology Search for Structure Prediction

“…Determining the 3D structure of proteins is of great importance to many research fields, encompassing cancer drug discovery (Ren et al 2023;Borkakoti and Thornton 2023), pesticide development, and crop improvement (Koesoema 2022). It also plays a crucial role in the design of sensors and enzymes (Pereira et al 2021), as well as numerous other applications, as reviewed by Pearce and Zhang (2021).…”