Proteins incorporated into biomimetically prepared calcium phosphate coatings modulate their mechanical strength and dissolution rate

Liu, Y; Hunziker, Ernst B.; Randall, Nicholas X.; Groot, K. de; Layrolle, Pierre

doi:10.1016/s0142-9612(02)00252-1

Cited by 148 publications

(112 citation statements)

References 23 publications

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“…In this way, the molecules can both sustain their biological activity for a considered period of time and support the mechanical properties of the coating in case of structural ECM components such as collagen. Both the biomimetic and electrospray deposition process (Table II) are among the most promising techniques for generating organic-inorganic composite coatings on implant materials due to their physiological process conditions (172)(173)(174).…”

Section: Organic-inorganic Composite Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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Section: Organic-inorganic Composite Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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“…Biocomposites of CDHA with water-soluble proteins, such as bovine serum albumin (BSA), might be prepared by a precipitation method [463,[689][690][691][692]. In such biocomposites, BSA is not strongly fixed to solid CDHA, which is useful for a sustained release.…”

Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…One of the problems associated with calcium phosphate implants is that they become fragile when soaked with the body fluids or blood, and this fragility may be attributable to the dissolution of Ca 2+ ions into the surrounding solution [17]. In this study, the bending and compression strengths of the implants soaked with 0.9% saline were significantly lower than the corresponding values for the controls, while the mechanical strength of the implants coated with trehalose did not decrease.…”

Section: Discussionmentioning

confidence: 51%

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

Choi

Lee

Igawa

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Artificial bone implants are often incorporated with osteoinductive factors to facilitate early bone regeneration. Calcium phosphate, the main component in artificial bone implants, strongly binds these factors, and in a few cases, the incorporated proteins are not released from the implant under conditions of physiological pH, thereby leading to reduction in their osteoinductivity. In this study, we coated tailor-made bone implants with trehalose to facilitate the release of basic fibroblast growth factor (bFGF). In an in vitro study, mouse osteoblastic cells were separately cultured for 48 hr in a medium with a untreated implant (T-), trehalose-coated implant (T+), bFGF-incorporated implant (FT-), and bFGF-incorporated implant with trehalose coating (FT+). In the FT+ group, cell viability was significantly higher than that in the other groups (P<0.05). Scanning electron microscopy (SEM) and X-ray diffraction (XRD) revealed that trehalose effectively covered the surface of the artificial bone implant without affecting the crystallinity or the mechanical strength of the artificial bone implant. These results suggest that coating artificial bone implants with trehalose could limit the binding of bFGF to calcium phosphate.KEY WORDS: artificial bone implant, bFGF, in vitro, trehalose.

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Proteins incorporated into biomimetically prepared calcium phosphate coatings modulate their mechanical strength and dissolution rate

Cited by 148 publications

References 23 publications

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

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