Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

Ng, Tzi Bun; Cheung, Randy Chi Fai; Wong, Jack Ho; Chan, Wai‐Yee

doi:10.1007/s00253-015-6997-z

Cited by 10 publications

(4 citation statements)

References 137 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45,46 Regarding basis, it was previously found that uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa. 47 In addition, nucleosides and/or nucleotides and their analogues showed inhibitory activity towards different viruses (e.g., HIV, HBV) 48,49 , and regulate virulence factors, biofilm formation and quorum sensing in Pseudomonas. 50 Our previous investigations showed about 25 fold higher concentration of quinic acid in an edible mushroom 51 (478 g g -1 fresh) than in C. intybus red chicory (<20 g g -1 fresh).…”

Section: Resultsmentioning

confidence: 99%

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

et al. 2018

View full text Add to dashboard Cite

The present study investigated the compounds present in the low molecular mass fraction of Lentinus edodes mushroom (shiitake) extract and their anti-virulence activity against oral pathogens (reference and clinical Streptococcus mutans, Actinomyces naeslundii, and Prevotella intermedia strains). Oxalic, succinic, and quinic acids, and adenine, inosine, and uridine were identified by HPLC-DAD-ESI-MS/MS. Their anti-biofilm production and preformed biofilm disaggregation activities were studied using commercial standard compounds at different concentrations. As regards S. mutans, the highest activity was shown by adenine at 5 mg mL-1 both in the biofilm inhibition (BI 50%) and biofilm disaggregation tests (BD 20%). Considering A. naeslundii, BI values close to 80% were registered for oxalic acid at 1 mg mL-1 and 2 mg mL-1 and BD 50% for quinic acid at 3 mg mL-1. A weaker activity was found against P. intermedia. Furthermore, different mixtures of the commercial standards were tested showing that the activity of a compound can be strongly and sometimes negatively affected by the presence of the other compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Finally, it should be noted that some bacterial and fungal enzymes targeting the sarcin-ricin loop have also been reported to possess antiviral activity [2,[67][68][69][70][71][72][73].…”

Section: Citotoxicity Of Ripsmentioning

confidence: 99%

“…Strategies are also being searched to tackle the challenge of plant viruses causing significant crop losses. This has led to the discovery of a number of antivirals with different chemical nature or proteins with different enzymatic activities [1,2]. The search for more effective and safer antivirals continues to be a field of intense investigation and plants are one of the most used sources, since they have evolved a variety of protein-based defense mechanisms to tackle viral infections [3].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Ribosome-Inactivating Proteins

Citores

Iglesias

Ferreras

2021

Toxins

View full text Add to dashboard Cite

Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.

show abstract

“…Antiviral effect. LF, β-LG, and α-LA have shown an antiviral role against human immunodeficiency virus (HIV) by inhibiting the activity of reverse transcriptase, integrase, and protease (Ng et al 2015).…”

Section: Minor Milk Proteinsmentioning

confidence: 99%

Comparison of extraction methods and nutritional benefits of proteins of milk and dairy products: A review

Javed¹,

Arshad²,

Arif³

et al. 2022

Czech J. Food Sci.

View full text Add to dashboard Cite

Proteins are the second most essential macromolecules after nucleic acids. This article aimed at the comparative analysis of extraction methods and nutritional benefits of milk and dairy products. Proteins form the body mass and perform several crucial tasks that include acting as a catalyst and carrying out different metabolic reactions in the body. Furthermore, protein acts as a transporter, transmits nerve impulses, provides mechanical support or immune protection, and controls growth. Several sources of proteins are present, but milk holds an important place due to its biological activities. The considerable health benefits of milk and its products are due to proteins. Yoghurt and cheese have significant importance among milk products. Proteins of milk and its products can be extracted by pH adjustment through homogenisation, centrifugation, and deproteinisation. There are several techniques for identifying and quantifying milk and product proteins. The Kjeldahl and spectrophotometric methods are the most widely used methods for quantifying proteins in milk and its products. Furthermore, these techniques include electrophoresis and chromatographic methods, including native gel electrophoresis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), urea-PAGE, capillary electrophoresis, and isoelectric focusing. A few are chromatographic methods like reverse-phase high-performance liquid chromatography (RP-HPLC), size exclusion chromatography, and ion-exchange chromatography. Each technique has its advantages as well as disadvantages. The selection of the process depends upon the type of protein. The extracted proteins from milk and its products have many health or therapeutic effects that exhibit antimicrobial, antiproliferative, antioxidant, antihypertensive, anticancer, antiviral, and immunomodulatory effects. Yoghurt has prime importance among milk products because of its therapeutic effects and more protein.

show abstract

Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

Cited by 10 publications

References 137 publications

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

Antiviral Activity of Ribosome-Inactivating Proteins

Comparison of extraction methods and nutritional benefits of proteins of milk and dairy products: A review

Contact Info

Product

Resources

About