2021
DOI: 10.1088/1755-1315/755/1/012016
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Proteolytic and Clot Lysis Activity Screening of Crude Proteases Extracted from Tissues and Bacterial Isolates of Holothuria Scabra

Abstract: Cardiovascular diseases (CVDs) are still the leading mortality causes in the last decades. The ailments are multifactorial characterized by excessive clot (thrombus) formation in the blood vessels. Thrombus could be degraded through thrombolysis mechanism by plasmin activated by various fibrinolysis agents including, urokinase, nattokinase, or streptokinase. However, the use of these agents is restricted by relatively high cost, short half-life, allergic reaction, and bleeding effects. The search for more econ… Show more

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Cited by 3 publications
(8 citation statements)
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“…The aim was to determine whether bacteria have the potential to produce proteases or not. The presence of proteolytic activity is indicated by the appearance of a clear zone around the bacteria [13,16] as shown in Figure 6. The clear zone formed around the colony was due to the ability of bacterial protease to degrade the casein substrate contained in the skim milk agar media.…”
Section: Proteolytic Testmentioning
confidence: 98%
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“…The aim was to determine whether bacteria have the potential to produce proteases or not. The presence of proteolytic activity is indicated by the appearance of a clear zone around the bacteria [13,16] as shown in Figure 6. The clear zone formed around the colony was due to the ability of bacterial protease to degrade the casein substrate contained in the skim milk agar media.…”
Section: Proteolytic Testmentioning
confidence: 98%
“…After obtaining a single isolate resulting from bacterial purification on NA media, the next step was to test the production of protease enzymes in Skim Milk Agar (SMA) producer media. Bacteria growing on NA media were scratched on SMA media and incubated for 24 h at 37 ℃ and then observed the formation of a clear zone around the colony growth [13,16,23].…”
Section: Isolation Of Protease-producing Bacteriamentioning
confidence: 99%
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