1960
DOI: 10.1002/cpt196012202
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Proteolytic enzymes: a therapeutic evaluation

Abstract: A promising development 0/ recent years has been the application of proteolytic enzymes to the therapy of disease in the human. Originally applied directly to the diseased area to efJect a local enzymatic debridement, proteolytic enzyme therapy is now being extended on a systemic basis to widen considerably the scope of its applicability. This report summarizes the current state of knowledge of proteolytic enzymes as therapeutic agents. It indicates those areas where the usefulness of proteolytic enzyme therap… Show more

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Cited by 62 publications
(13 citation statements)
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“…Plasmin actively lyses the fibrin that is the chief substance composing thrombi. Streptodornase acts by directly depolymerizing desoxyribonucleic acid and thus is thought to reduce the viscosity of purulent exudates (Sherry & Fletcher, 1960).…”
Section: Mechanism Of Actionmentioning
confidence: 99%
See 1 more Smart Citation
“…Plasmin actively lyses the fibrin that is the chief substance composing thrombi. Streptodornase acts by directly depolymerizing desoxyribonucleic acid and thus is thought to reduce the viscosity of purulent exudates (Sherry & Fletcher, 1960).…”
Section: Mechanism Of Actionmentioning
confidence: 99%
“…Therefore, most clinical trials have relied on investigators' subjective interpretations of results. Contributing further to this question of efficacy is the absence of evidence showing that enzymes are delivered intact by the circulation to the inflamed area, not having been previously affected by the powerful anti-proteolytic activity of serum (Sherry & Fletcher, 1960).…”
Section: Efficacymentioning
confidence: 99%
“…Enzymes are derived from plants (papase and bromelain), animals (trypsin and chymotrypsin), bacteria (streptokinase, streptodornase, and serratiopeptidase), and fungi [1].…”
Section: Introductionmentioning
confidence: 99%
“…For these reasons, cod trypsin has been tested and used for different biomedical applications. Trypsin and chymotrypsin from the pancreas of cattle or pigs have been used for decades as therapeutic agents in clinical trials for humans and animals [14–19]. The recombinant form of Atlantic cod trypsin has been produced in an active form in microorganisms [20, 21].…”
Section: Introductionmentioning
confidence: 99%