Proteome and transcriptome explore the mechanism of Salvia miltiorrhiza polysaccharides to relieve florfenicol-induced kidney injury in broilers

Lu, Chunyu; Zhang, Lu; Cui, Yuqing; Jin, Guozhong; Bao, Yongzhan; Shi, Wei

doi:10.1007/s11356-022-19114-0

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…As a novel broad-spectrum antibiotic for chloramphenicol in livestock, FFC could not only cause liver function damage but also lead to abnormal renal function, which may be caused by oxidative stress and abnormal renal cell apoptosis (Wang et al, 2021a;Wang et al, 2021b). Multiple studies have found that SMP has a protective effect on the kidney by reducing oxidative stress in the kidney, promoting drug metabolism enzymes and inhibiting apoptosis of renal tissue (Lu et al, 2022;Wang et al, 2022) Adding 1.5 g/kg SMP to weaned piglets significantly increased the ratio of ileum villus height to crypt depth, and changed the density and population of intestinal microflora, which improved the digestion and absorption ability of weaned piglets (Jiang et al, 2020).…”

Section: Other Significant Effectsmentioning

confidence: 99%

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Luo

Xue²,

Zheng³

et al. 2023

Front. Pharmacol.

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In recent years, natural polysaccharides have attracted more and more attention and research because of their value in the medicine, beauty and food fields. Salvia miltiorrhiza is a traditional Chinese herb that has been used for thousands of years and has antidiabetic, antifibrotic, neuroprotective, antioxidation, anti-inflammatory and other effects. It mainly includes rosmarinic acid, tanshinone I, tanshinone IIA, tanshinone IIB, procatechualdehyde, polysaccharide and salvianolic acids. Salvia miltiorrhiza polysaccharide is a polysaccharide extracted and isolated from Salvia miltiorrhiza and has diverse biological functions, including antioxidation, anti-tumor, hepatoprotective, anti-inflammatory, immune regulatory and cardioprotective effect. In this review, the extraction, purification, structural characterization and biological activity of SMPs are summarized and new perspectives for the future work of SMPs were also proposed, we hope our research can provide a reference for further research on SMPs.

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Section: Other Significant Effectsmentioning

confidence: 99%

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Luo

Xue²,

Zheng³

et al. 2023

Front. Pharmacol.

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“…In addition, the strength of immunity is closely related to that of the kidneys. In a renal injury model, SMPs alleviated renal injury by regulating blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), upregulating antioxidant enzymes GSH-Px and serum T-AOC, rapidly eliminating lipid peroxide (LPO) and ROS, and reducing oxidative stress in the kidney ( 117 ). Other studies have shown that SMPs combined with florfenicol (FFC) can improve the growth performance of broilers, increase the number of leukocyte subtypes in blood, increase the number of immunoglobulins (IgG, IgM, and IgA) and cytokines (IFN-γ and IL-2) in serum, and stimulate T cell proliferation and differentiation to activate cellular immunity.…”

Section: Plant Polysaccharidementioning

confidence: 99%

Research progress on the mechanisms underlying poultry immune regulation by plant polysaccharides

Zhao

Yang

Bai³

et al. 2023

Front. Vet. Sci.

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With the rapid development of poultry industry and the highly intensive production management, there are an increasing number of stress factors in poultry production. Excessive stress will affect their growth and development, immune function, and induce immunosuppression, susceptibility to a variety of diseases, and even death. In recent years, increasing interest has focused on natural components extracted from plants, among which plant polysaccharides have been highlighted because of their various biological activities. Plant polysaccharides are natural immunomodulators that can promote the growth of immune organs, activate immune cells and the complement system, and release cytokines. As a green feed additive, plant polysaccharides can not only relieve stress and enhance the immunity and disease resistance of poultry, but also regulate the balance of intestinal microorganisms and effectively alleviate all kinds of stress faced by poultry. This paper reviews the immunomodulatory effects and molecular mechanisms of different plant polysaccharides (Atractylodes macrocephala Koidz polysaccharide, Astragalus polysaccharides, Taishan Pinus massoniana pollen polysaccharide, and alfalfa polysaccharide) in poultry. Current research results reveal that plant polysaccharides have potential uses as therapeutic agents for poultry immune abnormalities and related diseases.

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“…Once the kidneys of broilers are damaged by excessive FFC, their development will be seriously hindered ( Wang et al, 2022 ). Previous studies found that FFC caused oxidative stress response in kidneys of chicks by inhibiting the expression of related factors in Nrf2-ARE pathway, and increased the apoptotic rate of renal histocytes by upregulating the expression of pro-apoptotic factors ( Wang et al, 2021b ; Lu et al, 2022 ). However, the effects of FFC on broiler kidneys are multifaceted, and its mechanisms are not completely clear.…”

Section: Introductionmentioning

confidence: 97%

Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway

Wang

Liu²,

Liu³

et al. 2022

Poultry Science

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Proteome and transcriptome explore the mechanism of Salvia miltiorrhiza polysaccharides to relieve florfenicol-induced kidney injury in broilers

Cited by 4 publications

References 32 publications

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Research progress on the mechanisms underlying poultry immune regulation by plant polysaccharides

Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway

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