Proteomic analysis of rat cortical neurons after fluoxetine treatment

Cecconi, Daniela; Mion, Silvia; Astner, Hubert; Domenici, Enrico; Righetti, Pier Giorgio; Carboni, Lucia

doi:10.1016/j.brainres.2006.12.008

Cited by 33 publications

(39 citation statements)

References 61 publications

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“…(For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) 14-3-3 protein z expression between the two research groups (Baik et al, 2005;Cecconi et al, 2007) may be caused by differences in analysis methods and target cells (RBL-2H3 cells versus cortical neurons). Furthermore, while Cecconi et al (2007) used 1 mM of fluoxetine as the concentration proportional to the lowest efficacious dose in behavioral models (Muscat et al, 1992), Baik et al (2005 used 10 mM of fluoxetine.…”

Section: Discussionmentioning

confidence: 96%

“…Their results implied that 14-3-3 protein, especially the z isoform, might be involved in the action mechanism of fluoxetine. However, Cecconi et al (2007) reported that fluoxetine treatment for 3 days led to the downregulation of 14-3-3 protein z/d, a brain-specific protein, in rat cortical neurons. They hypothesized that the opposite results of Fig.…”

Section: Discussionmentioning

confidence: 96%

“…Therefore, based on our results and the data from Duman et al (2000), it would be valuable to study whether 14-3-3 protein plays a specific role in the neuroprotective functions of fluoxetine. Recently, some studies observed an association between fluoxetine and 14-3-3 protein (Baik et al, 2005;Cecconi et al, 2007). In a study by Baik et al (2005), it was reported that the mRNA and protein levels of 14-3-3 z, one of the seven known isoforms, was upregulated after fluoxetine treatment for 2 and 3 days in rat basophilic RBL-2H3 cells, which have an active 5-HT system.…”

Section: Discussionmentioning

confidence: 97%

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Effect of fluoxetine on the expression of tryptophan hydroxylase and 14-3-3 protein in the dorsal raphe nucleus and hippocampus of rat

Choi

Hwang

Park

et al. 2012

Journal of Chemical Neuroanatomy

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

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Effect of fluoxetine on the expression of tryptophan hydroxylase and 14-3-3 protein in the dorsal raphe nucleus and hippocampus of rat

Choi

Hwang

Park

et al. 2012

Journal of Chemical Neuroanatomy

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“…190 In addition, expression of some 14-3-3 genes is sensitive to drugs used to treat psychiatric illness, since 14-3-3b is upregulated in PFC of monkeys treated with the neuroleptic haloperidol 190 and levels of 14-3-3d and 14-3-3z are altered in rat cortical neurons in response to application of the antidepressant fluoxetine. 191 …”

Section: Lis1 Ndel1 Nde1 and Disc1mentioning

confidence: 99%

The DISC locus in psychiatric illness

et al. 2007

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The DISC locus is located at the breakpoint of a balanced t(1;11) chromosomal translocation in a large and unique Scottish family. This translocation segregates in a highly statistically significant manner with a broad diagnosis of psychiatric illness, including schizophrenia, bipolar disorder and major depression, as well as with a narrow diagnosis of schizophrenia alone. Two novel genes were identified at this locus and due to the high prevalence of schizophrenia in this family, they were named Disrupted-in-Schizophrenia-1 (DISC1) and Disrupted-in-Schizophrenia-2 (DISC2). DISC1 encodes a novel multifunctional scaffold protein, whereas DISC2 is a putative noncoding RNA gene antisense to DISC1. A number of independent genetic linkage and association studies in diverse populations support the original linkage findings in the Scottish family and genetic evidence now implicates the DISC locus in susceptibility to schizophrenia, schizoaffective disorder, bipolar disorder and major depression as well as various cognitive traits. Despite this, with the exception of the t(1;11) translocation, robust evidence for a functional variant(s) is still lacking and genetic heterogeneity is likely. Of the two genes identified at this locus, DISC1 has been prioritized as the most probable candidate susceptibility gene for psychiatric illness, as its protein sequence is directly disrupted by the translocation. Much research has been undertaken in recent years to elucidate the biological functions of the DISC1 protein and to further our understanding of how it contributes to the pathogenesis of schizophrenia. These data are the main subject of this review; however, the potential involvement of DISC2 in the pathogenesis of psychiatric illness is also discussed. A detailed picture of DISC1 function is now emerging, which encompasses roles in neurodevelopment, cytoskeletal function and cAMP signalling, and several DISC1 interactors have also been defined as independent genetic susceptibility factors for psychiatric illness. DISC1 is a hub protein in a multidimensional risk pathway for major mental illness, and studies of this pathway are opening up opportunities for a better understanding of causality and possible mechanisms of intervention. Molecular Psychiatry (2008) 13, 36-64; doi:10.1038/sj.mp.4002106; published online 2 October 2007 Keywords: schizophrenia; bipolar disorder; depression; DISC1; DISC2; mouse models Genetics of DISC1 discoverySt Clair et al. 1 first reported a Scottish family with a high loading of major mental illness, which cosegregates with a t(1;11) translocation. Long-term follow-up of this family over a period of 30 years has reported 87 family members, of whom 37 carry the translocation. 2 Of 29 individuals carrying the translocation, for whom psychiatric assessment was possible, 7 have a diagnosis of schizophrenia, 1 has a diagnosis of bipolar disorder and 10 cases of recurrent major depression were also reported. 2 Thus, 18 of 29 translocation carriers are diagnosed with major mental illness whereas none of...

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“…Note that the cells trapped in the microwells included both neurons and glial cells. Some studies showed that cortex of 18-day-old rat embryo contained about 80% of neurons and remaining cells were non-neuronal cells including glial cells (13,14). Thus, the number of neurons trapped in the small microwells was estimated to be three to six for large-wells and single to three for small-wells.…”

mentioning

confidence: 98%