2024
DOI: 10.1128/msystems.01338-23
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Proteomic and transcriptomic analysis of selenium utilization in Methanococcus maripaludis

Katrina Funkner,
Anja Poehlein,
Nico Jehmlich
et al.

Abstract: Methanococcus maripaludis utilizes selenocysteine- (Sec-) containing proteins (selenoproteins), mostly active in the organism’s primary energy metabolism, methanogenesis. During selenium depletion, M. maripaludis employs a set of enzymes containing cysteine (Cys) instead of Sec. The genes coding for these Sec-/Cys-containing isoforms were the only genes known of which expression is influenced by the selenium status of the cell. Using proteomics and transcriptomics, app… Show more

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