Proteomic Approach to Understanding Antibiotic Action

Bandow, Julia E.; Brötz, Heike; Leichert, Lars I.; Labischinski, Harald; Hecker, Michael

doi:10.1128/aac.47.3.948-955.2003

Cited by 302 publications

(275 citation statements)

References 35 publications

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“…Today, the infectious diseases have become worldwide a leading cause of death, therefore, their study has become a global concern [40]. The emergence of multidrugresistance in the pathogens is threatening the clinical efficiency of many existing antibiotics [41]. It is a matter of fact that a number of infectious diseases have been treated with herbal medicines throughout the history of mankind.…”

Section: History Of Medicinal Plantsmentioning

confidence: 99%

Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan

Mustafa¹,

Arif²,

Atta³

et al. 2017

Matrix sci. pharma

126

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Humans have relied on nature throughout their ages to cater for their basic needs including medicines to cure a wide spectrum of diseases. Plants have formed the basis for sophisticated systems of traditional medicines. For therapeutic agents many of the presently known lead compounds are natural products or their derivatives. Ethnomedicinal studies play a vital role to discover new drugs from indigenous medicinal plants. Green pharmaceuticals are getting popularity and extraordinary importance because vast opportunities for new drug discoveries are provided by the unmatched availability of chemical diversity and natural products either as pure compounds or as homogenous plant extracts. Therefore, in recent years the demand for herbal medicines and several natural products from a variety of plant species is consistently increasing. In spite of being an agricultural country and having different ecological regions, the medicinal plants of Pakistan have not been explored for their secondary metabolites which are responsible for treating different diseases. Although, huge importance of different extracts of medicinal plants from Pakistan have been reported for their different activities such as antimicrobial, anti-cancerouse, antiviral and antioxidant but complete biochemical profiling of these medicinal plants is lacking. LC-MS and GC-MS techniques have been applied in the field of drug discovery from medicinal plants but in Pakistan its success rate is very low in the subject of biochemical profiling. Therefore, such techniques should be used in Pakistan to explore active constituents from medicinal plants which could be used as medicines in future.

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Section: History Of Medicinal Plantsmentioning

confidence: 99%

Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan

Mustafa¹,

Arif²,

Atta³

et al. 2017

Matrix sci. pharma

126

View full text Add to dashboard Cite

show abstract

“…The clinical efficacy of many existing antibiotics is being threatened by the emergence of multidrug-resistant pathogens (Bandow et al, 2003). Plant products, either as pure compounds or as standardized extracts, provide promising opportunities for new anti-infective drugs.…”

Section: Various Pathogenic Bacteria Including Escherichia Coli Andmentioning

confidence: 99%

Antibacterial Activity of Triterpenoids from Clerodendron trichotomum

Choi¹,

Cho²,

Lee³

et al. 2012

Journal of Applied Biological Chemistry

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The aim of this research was to investigate the antibacterial activity of Clerodendron trichotomum. Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate, and n-butanol fractions from C. trichotomum were tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori. The n-hexane and MC fractions showed antibacterial activity against H. pylori at a concentration of 1.7 mg/mL and showed inhibition zones of 10 and 11 mm in disc assay, respectively. Further testing of 22-dehydroclerosterol and β-amyrin (each 3.4 mg/mL) from the MC fraction of C. trichotomum revealed moderate antibacterial effects against E. coli, S. aureus, and H. pylori. In particular, β-amyrin showed clear zones of 12 and 13 mm against E. coli and H. pylori, respectively, suggesting its potential as an antibacterial agent. The active compounds from C. trichotomum might provide a promising therapeutic agent against infections by E. coli, S. aureus, and H. pylori.

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“…The barks of different species of Juglans regia have been chemically analyzed in numerous studies. Major components in obtained essential oils of Juglans regia include phenolic compounds, terpenoids, alkaloids, flavonoids and steroids (17). It is reported that the bark of Juglans regia Li.…”

Section: Introductionmentioning

confidence: 99%

Effect of Juglans regia Li. Stem Bark Hydroalcoholic Extract on Methicillin Resistant Staphylococcus aureus

Bakhtiari

Jamshidian

Khalafi

2016

Jundishapur J Nat Pharm Prod

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Background: Methicillin-resistant Staphylococcus aureus (MRSA) is considered a major cause of nosocomial and community infections. Its prevalence varies from country to country, even between hospitals of a country. These bacteria often have multi-resistance and can be difficult to treat. Objectives: The current study evaluated the effect of hydroalcoholic extract of the stem bark of Juglans regia Li. on several isolated methicillin-resistant Staphylococcus aureus. Materials and Methods: A total of 50 S. aureus strains were isolated from various clinical specimens and antibiotic susceptibility and presence of methicillin-resistant gene (mecA) were evaluated using disc diffusion and polymerase chain reaction (PCR) methods. The effect of hydroalcoholic extract on MRSA was evaluated by E-test and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. Results: All of 50 MRSA strains were multi-drug resistant. All MRSA strains were found resistant to penicillin, ampicillin and methicillin. A low resistance was observed toward erythromycin (48%) and then ciprofloxacin, gentamycin and clindamycin (34%). All strains except one were sensitive to vancomycin. All strains except one were mecA carrier in PCR and hydroalcoholic extract had significant antibacterial effect on MRSA compared to positive control. Minimum inhibitory and bactericidal concentrations were 7.81 mg/mL and 3.9 mg/mL, respectively. Conclusions: The hydroalcoholic extract of Juglans regia Li. proved to have a good effect against MRSA. In this respect, this extract can be used as a commercial disinfectant in the form of spray or solution in hospitals and public places.

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Proteomic Approach to Understanding Antibiotic Action

Cited by 302 publications

References 35 publications

Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan

Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan

Antibacterial Activity of Triterpenoids from Clerodendron trichotomum

Effect of Juglans regia Li. Stem Bark Hydroalcoholic Extract on Methicillin Resistant Staphylococcus aureus

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