2020
DOI: 10.3390/vaccines8030463
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Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

Abstract: Tick-borne diseases affecting humans and animals are on the rise worldwide. Vaccines constitute an effective control measure, but very few are available. We selected Lyme borreliosis, a bacterial infection transmitted by the hard tick Ixodes, to validate a new concept to identify vaccine candidates. This disease is the most common tick-borne disease in the Northern Hemisphere. Although attempts to develop a vaccine exist, none have been successfully marketed. In tick-borne diseases, the skin constitutes a very… Show more

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Cited by 9 publications
(4 citation statements)
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References 64 publications
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“…Antibody to OspC develops early and can be detected in the serum of mice within two weeks of syringe inoculation of B. burgdorferi (Oliver Jr et al, 2016). Consistent with this, nontargeted mass spectrometry of skin biopsies collected from mice seven days after delivery of B. burgdorferi by syringe inoculation also identified OspC as one of the most frequently detected B. burgdorferi proteins (Talagrand-Reboul et al, 2020).…”
Section: Outer Surface Protein C (Ospc) Expression Structure and Functionsupporting
confidence: 59%
“…Antibody to OspC develops early and can be detected in the serum of mice within two weeks of syringe inoculation of B. burgdorferi (Oliver Jr et al, 2016). Consistent with this, nontargeted mass spectrometry of skin biopsies collected from mice seven days after delivery of B. burgdorferi by syringe inoculation also identified OspC as one of the most frequently detected B. burgdorferi proteins (Talagrand-Reboul et al, 2020).…”
Section: Outer Surface Protein C (Ospc) Expression Structure and Functionsupporting
confidence: 59%
“…It might be used to identify tick saliva proteins inoculated into the host skin. Targeted proteomics will be also very useful to identify vaccine candidates (325). To develop effective vaccines against VBDs, after identification of good vaccine candidates, efficient delivery system will be necessary in the future to take into consideration the skin microbiome and the skin immunity (326).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, advanced mass spectrometry-based proteomics provide unmatched information such as protein identification, quantification and post-translational modifications. The characterization of the Bb proteome enables basic science research and the development of vaccines and diagnostics (44,165). Though several proteomic studies have been published, no highresolution mass spectrometry (MS) data is represented in a publicly accessible repository for the community to access and utilize in research goals (162,166,167).…”
Section: Proteomic Insights From Borreliaceae Lineagesmentioning
confidence: 99%