2006
DOI: 10.1152/physiolgenomics.00323.2005
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Proteomics and genomics of microgravity

Abstract: Many serious adverse physiological changes occur during spaceflight. In the search for underlying mechanisms and possible new countermeasures, many experimental tools and methods have been developed to study microgravity caused physiological changes, ranging from in vitro bioreactor studies to spaceflight investigations. Recently, genomic and proteomic approaches have gained a lot of attention; after major scientific breakthroughs in the fields of genomics and proteomics, they are now widely accepted and used … Show more

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Cited by 62 publications
(57 citation statements)
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“…Microgravity is a hostile environment for living species the microgravity environment induces stress as evidenced by data obtained from animal studies performed in real space shuttle missions and also in simulated microgravity conditions [2,8,9]. The ground-based model for studying microgravity used in this study causes shifting of fluids in the brain, similar to that experienced by astronauts in space.…”
Section: Resultsmentioning
confidence: 89%
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“…Microgravity is a hostile environment for living species the microgravity environment induces stress as evidenced by data obtained from animal studies performed in real space shuttle missions and also in simulated microgravity conditions [2,8,9]. The ground-based model for studying microgravity used in this study causes shifting of fluids in the brain, similar to that experienced by astronauts in space.…”
Section: Resultsmentioning
confidence: 89%
“…The changes were seen in balance, eye movements and reflex control of cardiovascular, respiratory and gastrointestinal functions [1,2]. These activities are directly or indirectly related to the changes that occur due to the activity of the brain under zero gravity in space.…”
Section: Introductionmentioning
confidence: 99%
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“…SRF was shown to be mediated by the Rho signaling pathway (25)(26)(27), which may have been triggered by the RPM. Rho signaling is believed to be an important pathway for focal adhesion assembly and cytoskeleton remodeling in response to cellular tension stress (28) and has been suggested to play a role in the microgravity response (21,(29)(30)(31). Furthermore, Rho GTPase activities were shown to be increased in dermal fibroblasts subjected to simulated microgravity for 30 and 120 min, thereafter decreasing to reach similar values to those of the CTRL at 48 h of treatment (32).…”
Section: The Rpm Has a Dominant Impact On Single Gene Expressionmentioning
confidence: 99%
“…While it has been shown in various cell types that cytoskeleton remodeling starts immediately after exposure to simulated or real microgravity (21,(29)(30)(31), few studies investigated the effects of IR on the cytoskeleton. However, therapeutic doses of irradiation were shown to affect cell permeability of microvascular endothelial cells through Rho-mediated cytoskeleton remodeling (37).…”
Section: The Rpm Has a Dominant Impact On Single Gene Expressionmentioning
confidence: 99%