Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator‐activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver

Abstract

Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non‐polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of LDs in cells is closely related to the development and progression of many diseases in humans and animals, such as liver‐related and cardiovascular diseases. Thus, regulating the LDs size and abundance is necessary to maintain metabolic homeostasis. This study found that lipopolysaccharide (LPS) stimulation reduced the LDs content in the mouse liver. We tried to explain the possible molecular mechanisms at the broad protein and mRNA levels, finding that inhibition of the peroxisome proliferator‐activated receptors (PPAR) signalling pathway by LPS may be a critical factor in reducing LDs content.