Proteomics in transfusion medicine

Reddy, Kalpana; Perrotta, Peter L.

doi:10.1111/j.1537-2995.2004.03343.x

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…Proteomics is becoming important for all medical specialties, notably hematology, and several papers have been published in leading hematology journals in order to introduce the subject to nonspecialists [4,133,178,179]. Here we have highlighted some of the progress achieved recently by studying the proteome of plasma/serum as well as of blood cells, and have shown that, in the near future, proteomics certainly will change the face of hematology.…”

Section: Discussionmentioning

confidence: 95%

Recent advances in blood‐related proteomics

et al. 2005

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Service régional vaudois de transfusion sanguine, Lausanne, SwitzerlandBlood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has permitted the development of prognostic and diagnostic indicators for disease. The recent advance in MS and protein separation now allows similar progress in the analysis of proteins. Proteomics offers great promise for the study of proteins in plasma/serum, indeed a number of proteomics databases for plasma/ serum have been established. This is a very complex body fluid containing lipids, carbohydrates, amino acids, vitamins, nucleic acids, hormones, and proteins. About 1500 different proteins have recently been identified, and a number of potential new markers of diseases have been characterized. Here, examples of the enormous promise of plasma/serum proteomic analysis for diagnostic/prognostic markers and information on disease mechanism are given. Within the blood are also a large number of different blood cell types that potentially hold similar information. Proteomics of red blood cells, until now, has not improved our knowledge of these cells, in contrast to the major progresses achieved while studying platelets and leukocytes. In the future, proteomics will change several aspects of hematology.

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Section: Discussionmentioning

confidence: 95%

Recent advances in blood‐related proteomics

et al. 2005

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“…The "Whatomics" (a term coined by D. J. Anstee [133]) is a new reality for everybody involved in transfusion medicine. Tutorial papers dealing with either proteomics or proteomics and genomics have been published in journals dedicated to transfusion medicine [134][135][136]. Transfusion medicine is evolving.…”

Section: Discussionmentioning

confidence: 99%

Proteomics and transfusion medicine: Future perspectives

et al. 2006

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Limited number of important discoveries have greatly contributed to the progresses achieved in the blood transfusion; ABO histo-blood groups, citrate as anticoagulant, fractionation of plasma proteins, plastic bags and apheresis machines. Three major types of blood products are transfused to patients: red cell concentrates, platelet concentrates and fresh frozen plasma. Several parameters of these products change during storage process and they have been well studied over the years. However, several aspects have completely been ignored; in particular those related to peptide and protein changes. This review presents what has been done using proteomic tools and the potentials of proteomics for transfusion medicine.

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“…Herein, we summarize the current state of the application of proteomics to the challenges in transfusion medicine, both at the donor assessment level and at the level of component preparation and quality. Others have come before us, and the reader is referred to additional descriptions of the recent advances in the application of proteomics in transfusion medicine summarized in these excellent review articles [4–7].…”

Section: Continuous Improvement In Blood Bankingmentioning

confidence: 99%