Proteomics of the phase angle: Results from the population-based KORA S4 study

Huemer, Marie-Theres; Petrera, Agnese; Hauck, Stefanie M.; Drey, Michael; Peters, Annette; Thorand, Barbara

doi:10.1016/j.clnu.2022.06.038

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Second, PhA negatively correlated with NT-proBNP, possibly indicating a more severe cardiovascular condition. NT-proBNP has been reported to be a key marker of PhA in a previous study, 25 and an independent relationship between NT-proBNP and PhA was observed in the present study, supporting this hypothesis. Finally, preoperative systemic health conditions may be associated with the post-discharge prognosis.…”

Section: Discussionsupporting

confidence: 91%

Association between preoperative phase angle and all‐cause mortality after cardiovascular surgery: A retrospective cohort study

Shibata,

Kameshima,

Adachi

et al. 2024

J cachexia sarcopenia muscle

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BackgroundThe importance of preoperative physical function assessment for post‐operative intervention has been reported in older patients undergoing cardiovascular surgery. Phase angle (PhA), measured using bioelectrical impedance analysis, is an indicator of cellular health and integrity and is reported as a prognostic factor in several chronic diseases; however, its association with the long‐term prognosis of cardiovascular surgery remains unclear. This study aimed to investigate the prognostic value of PhA for long‐term mortality in patients undergoing cardiovascular surgery.MethodsThis retrospective cohort study included consecutive patients who underwent elective cardiovascular surgery between October 2016 and March 2021 at Nagoya Heart Center, Japan. PhA was assessed using bioelectrical impedance analysis before surgery, and physical function measures (gait speed, grip strength and short physical performance battery [SPPB]) were measured synchronously. The association between PhA and all‐cause mortality after discharge was assessed using Kaplan–Meier and multivariate Cox regression analyses. The incremental prognostic value of PhA was compared with other physical function measures using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).ResultsA total of 858 patients were included in the present analysis (mean age = 68.4 ± 11.9 years, 67.6% male). PhA positively correlated with body mass index (ρ = 0.38, P < 0.001), skeletal muscle mass index (ρ = 0.58, P < 0.001), usual gait speed (ρ = 0.44, P < 0.001), grip strength (ρ = 0.73, P < 0.001) and SPPB (ρ = 0.51, P < 0.001). The mean follow‐up period, within which 44 (4.7%) died, was 908.9 ± 499.9 days for the entire cohort. Kaplan–Meier survival curves based on the PhA tertiles showed that higher PhA was associated with better survival (log‐rank test, P < 0.001). The Cox regression analysis showed the independent association of PhA with mortality risk (hazard ratio: 0.91 per 0.1° increment; 95% confidence interval [CI]: 0.87–0.95; P < 0.001). The NRI and IDI showed significant improvements in predicting mortality after adding PhA to the clinical model consisting of age, sex and cardiac and renal function (NRI: 0.426, 95% CI: 0.124–0.729, P = 0.006; IDI: 0.037, 95% CI: 0.012–0.062, P = 0.003). The predictive model consisting of the clinical model and PhA was superior to the model consisting of the clinical model and each of the other physical function indicators (P < 0.05).ConclusionsPhA correlated with physical function and independently predicted long‐term mortality after cardiovascular surgery. The additive prognostic value of PhA compared with the other physical function measures suggests the clinical usefulness of preoperative PhA for risk stratification in planning post‐operative treatment and rehabilitation.

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Section: Discussionsupporting

confidence: 91%

Association between preoperative phase angle and all‐cause mortality after cardiovascular surgery: A retrospective cohort study

Shibata,

Kameshima,

Adachi

et al. 2024

J cachexia sarcopenia muscle

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“…The authors found that N-terminal prohormone brain natriuretic peptide (a marker of heart failure) was a significant PhA marker. They also indicated that the biological process related to PhA’s protein profile was involved in the protein profile control of cell quantity and growth, supporting the consensus that PhA reflects body cell mass from a biomedical perspective [ 61 ].…”

Section: Phase Angle and Its Determinantsmentioning

confidence: 74%

“…Proteomics is a cutting-edge application of technologies for identifying and quantifying the total amount of proteins in a cell, tissue, or organism [ 60 ]. Huemer et al, 2022 employed proteomics to investigate PhA’s biomedical factors by identifying protein markers and its related biological processes [ 61 ]. The authors found that N-terminal prohormone brain natriuretic peptide (a marker of heart failure) was a significant PhA marker.…”

Section: Phase Angle and Its Determinantsmentioning

confidence: 99%

Phase angle and cellular health: inflammation and oxidative damage

Silva

Orsso

Gonzalez

et al. 2022

Rev Endocr Metab Disord

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Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.

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“…While the relationship between phase angle and overall body cell mass (BCM) has been described early, only recently, a study also confirmed an association between phase angle and cell growth and metabolism in healthy older adults. Using a proteomics approach, six protein markers were identified as being strongly associated with the phase angle [12]. When the protein markers were grouped according to their functional characteristics, regulation of the amount and growth of cells emerged as the main biological process which is related to the phase angle [12].…”

mentioning

confidence: 99%

“…Using a proteomics approach, six protein markers were identified as being strongly associated with the phase angle [12]. When the protein markers were grouped according to their functional characteristics, regulation of the amount and growth of cells emerged as the main biological process which is related to the phase angle [12]. N-terminal pro b-type natriuretic peptide (NT-proBNP) was the key marker of the phase angle.…”

mentioning

confidence: 99%

Role of phase angle in older adults with focus on the geriatric syndromes sarcopenia and frailty

Norman

Müller‐Werdan

2022

Rev Endocr Metab Disord

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Body composition is known to change with aging hallmarked by a decline in skeletal muscle mass as well as by an increase in total and abdominal fat tissue. As changes in body composition are associated with increased risk for disease and disability, monitoring body composition in the old is of clinical importance.Sarcopenia has been referred to as a geriatric syndrome [1] as it describes the age-associated loss of muscle mass and function, which is accompanied by a progressive decline in physical performance and is associated with a higher risk for physical disability and need for care. Sarcopenia can be AbbreviationsBCM Body cell mass BIA Bioelectrical impedance analysis BMI Body mass index CT Computed tomography DXA Dual X-ray absorptiometry FraDySMex Frailty, Dynapenia, and Sarcopenia in

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Proteomics of the phase angle: Results from the population-based KORA S4 study

Cited by 7 publications

References 47 publications

Association between preoperative phase angle and all‐cause mortality after cardiovascular surgery: A retrospective cohort study

Association between preoperative phase angle and all‐cause mortality after cardiovascular surgery: A retrospective cohort study

Phase angle and cellular health: inflammation and oxidative damage

Role of phase angle in older adults with focus on the geriatric syndromes sarcopenia and frailty

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