Proteomics profile of cellular response to chiral drugs: Prospects for pharmaceutical applications

Abstract

Chiral drugs account for a large proportion of drugs available in the market. There is increasing awareness of the importance of drug chirality and the role it plays in explaining the oftentimes dramatic differences in biological activities in the current drug development portfolio. Using recently developed chiral drugs-cell interaction system, several examples of protein profiles induced by chiral drugs were illustrated in detail on the platform of 2-D LC interfaced with MS/MS system. In addition, the background of chiral drug investigation from which contemporary drug chirality research has emerged, the techniques involved in proteomics technology, the application of proteomics in this exciting area, and the perspectives in future applications are also discussed.

Advantages of electronic circular dichroism detection for the stereochemical analysis and characterization of drugs and natural products by liquid chromatography

“…Consequently, analytical techniques allowing for the stereochemistry to be fully characterized are receiving increasing attention, as requested by regulatory agencies, for the quality control of chiral drugs due to the strong impact of stereochemistry on both safety and efficiency [24][25][26][27][28][29][30]. In addition, stereochemical analysis gives a key contribution to the understanding of biorecognition processes involving the binding of drugs to their targets and the modulation of their function; this information is essential for a rational design of new potent and selective drugs and the optimization of their pharmacokinetics profiles [31][32][33][34].…”