Proteomics reveals surface electrical property-dependent toxic mechanisms of silver nanoparticles in Chlorella vulgaris

Zhang, Jilai; Shen, Lin; Xiang, Qian-Qian; Ling, Jian; Zhou, Chuan-Hua; Hu, Jinming; Chen, Liqiang

doi:10.1016/j.envpol.2020.114743

Cited by 18 publications

(16 citation statements)

References 63 publications

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“…This finding can be explained by Ag + internalization into cell through Cu(I) transporter. Particularly interesting is the study of Zhang et al [ 29 ], who compared effects of two differently coated AgNPs, negatively charged AgNP-citrate and positively charged AgNP-PEI, on protein expression in C. vulgaris , and revealed that citrate-coated AgNPs induced downregulation of mitochondrial function-related proteins, resulting in the disruption of metabolic pathways related to energy metabolism, oxidative phosphorylation, and amino acid synthesis. On the other hand, positively charged AgNP-PEI primarily targeted ribosome function-related proteins and interrupted pathways of protein synthesis and DNA genetic information transmission.…”

Section: Changes In Gene and Protein Expressionmentioning

confidence: 99%

“…[ 26 ], and in Pithophora oedogonia and Chara vulgaris [ 27 ] ( Table 1 ). Only a few studies performed on freshwater algae have investigated AgNP influence on oxidative stress induction [ 21 , 25 ] and protein expression [ 21 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Besides PVP, polyethylene glycol (PEG) and polyvinyl alcohol (PVA) have also been frequently used for AgNP stabilization in both plant [ 52 , 53 , 54 , 55 , 56 , 57 ] and algal research [ 19 , 20 , 26 , 28 ], while GA, a natural polymer consisting of polysaccharides and glycoproteins, has mostly been utilized in plant studies [ 10 , 46 , 58 , 59 ]. Considering the electrostatic stabilization of AgNPs, citrate is the most commonly applied coating that provides a negative charge, and it has been employed in many toxicology studies performed on both plants [ 47 , 50 , 51 , 60 , 61 , 62 , 63 ] and algae [ 20 , 21 , 22 , 29 , 33 , 37 , 40 , 41 , 64 ]. On the other hand, positively charged AgNPs have been scarcely used in plant studies and were usually obtained by application of cationic surfactant CTAB [ 50 , 51 , 65 ], although didecyldimethylammonium bromide (DDAB) [ 66 ] or polyhexamethylene biguanide (PHMB) [ 67 ] have also been employed.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, positively charged AgNPs have been scarcely used in plant studies and were usually obtained by application of cationic surfactant CTAB [ 50 , 51 , 65 ], although didecyldimethylammonium bromide (DDAB) [ 66 ] or polyhexamethylene biguanide (PHMB) [ 67 ] have also been employed. Cationic polymer polyethyleneimine (PEI) was applied as AgNP coating in the study on freshwater algae C. vulgaris [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Surface Coating-Modulated Phytotoxic Responses of Silver Nanoparticles in Plants and Freshwater Green Algae

et al. 2021

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Silver nanoparticles (AgNPs) have been implemented in a wide range of commercial products, resulting in their unregulated release into aquatic as well as terrestrial systems. This raises concerns over their impending environmental effects. Once released into the environment, they are prone to various transformation processes that modify their reactivity. In order to increase AgNP stability, different stabilizing coatings are applied during their synthesis. However, coating agents determine particle size and shape and influence their solubility, reactivity, and overall stability as well as their behavior and transformations in the biological medium. In this review, we attempt to give an overview on how the employment of different stabilizing coatings can modulate AgNP-induced phytotoxicity with respect to growth, physiology, and gene and protein expression in terrestrial and aquatic plants and freshwater algae.

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Section: Changes In Gene and Protein Expressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surface Coating-Modulated Phytotoxic Responses of Silver Nanoparticles in Plants and Freshwater Green Algae

et al. 2021

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“…On the contrary, negative AgNPs have a low affinity for the anionic cell membrane, which would reduce the adsorption or internalization of NPs by algal cells. Additionally, Zhang et al (2020a ) analysed the toxic mechanisms of AgNPs with different surface electrical charges in C. vulgaris using a proteomics approach. The positively charged AgNPs interfered with pathways related to protein synthesis and DNA genetic information transmission.…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Corsi

Desimone

Cazenave

2022

Front. Bioeng. Biotechnol.

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Nanotechnologies have rapidly grown, and they are considered the new industrial revolution. However, the augmented production and wide applications of engineered nanomaterials (ENMs) and nanoparticles (NPs) inevitably lead to environmental exposure with consequences on human and environmental health. Engineered nanomaterial and nanoparticle (ENM/P) effects on humans and the environment are complex and largely depend on the interplay between their peculiar properties such as size, shape, coating, surface charge, and degree of agglomeration or aggregation and those of the receiving media/body. These rebounds on ENM/P safety and newly developed concepts such as the safety by design are gaining importance in the field of sustainable nanotechnologies. This article aims to review the critical characteristics of the ENM/Ps that need to be addressed in the safe by design process to develop ENM/Ps with the ablility to reduce/minimize any potential toxicological risks for living beings associated with their exposure. Specifically, we focused on silver nanoparticles (AgNPs) due to an increasing number of nanoproducts containing AgNPs, as well as an increasing knowledge about these nanomaterials (NMs) and their effects. We review the ecotoxicological effects documented on freshwater and marine species that demonstrate the importance of the relationship between the ENM/P design and their biological outcomes in terms of environmental safety.

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Proteomic evaluation of nanotoxicity in aquatic organisms: A review

2022

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The alteration of organisms protein functions by engineered nanoparticles (ENPs) is dependent on the complex interplay between their inherent physicochemical properties (e.g., size, surface coating, shape) and environmental conditions (e.g., pH, organic matter). To date, there is increasing interest on the use of 'omics' approaches, such as proteomics, genomics, and others, to study ENPs-biomolecules interactions in aquatic organisms. However, although proteomics has recently been applied to investigate effects of ENPs and associated mechanisms in aquatic organisms, its use remain limited. Herein, proteomics techniques widely applied to investigate ENPs-protein interactions in aquatic organisms are reviewed. Data demonstrates that 2DE and mass spectrometry and/or their combination, thereof, are the most suitable techniques to elucidate ENPs-protein interactions. Furthermore, current status on ENPs and protein interactions, and possible mechanisms of nanotoxicity with emphasis on those that exert influence at protein expression levels, and key influencing factors on ENPs-proteins interactions are outlined. Most reported studies were done using synthetic media and essay protocols and had wide variability (not standardized); this may consequently limit data application in actual environmental systems. Therefore, there is a need for studies using realistic environmental concentrations of ENPs, and actual environmental matrixes (e.g., surface water) to aid better model development of ENPs-proteins interactions in aquatic systems.

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Proteomics reveals surface electrical property-dependent toxic mechanisms of silver nanoparticles in Chlorella vulgaris

Cited by 18 publications

References 63 publications

Surface Coating-Modulated Phytotoxic Responses of Silver Nanoparticles in Plants and Freshwater Green Algae

Surface Coating-Modulated Phytotoxic Responses of Silver Nanoparticles in Plants and Freshwater Green Algae

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Proteomic evaluation of nanotoxicity in aquatic organisms: A review

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