Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation

Abstract

Prothrombinex-VF is very effective and safe when used alone to reverse warfarin anticoagulation. The supplementary use of fresh frozen plasma in these patients is not required. A review of the current Warfarin Reversal Consensus Guidelines is needed.

Warfarin‐related intracerebral haemorrhage: better outcomes when reversal includes prothrombin complex concentrates

“…25,36 However, the three-factor PCC used in our institution (Prothrombinex-HT 37 ) may not contain sufficient factor VII, and given the dire consequences of inadequate reversal, this is covered by using small volumes of FFP.…”

Clinical Experience With Three-Factor Prothrombin Complex Concentrate to Reverse Warfarin Anticoagulation in Intracranial Hemorrhage

“…No thrombotic events were reported in studies of other 3-factor PCC products, such as Prothrombinex VF or Uman Complex DI, within 1 month of treatment. 7,8 Thrombotic complications were uncommon in 2 large series of patients treated with 4-factor PCC. 9,10 This study has several limitations.…”

Prothrombin complex concentrates in emergency bleeding disorders

“…Numerous, mostly small, clinical studies have shown that in the VKA-reversal setting, PCCs can be effective in rapidly reversing elevated INR values, improving hemostasis, and in elevating coagulation factors in patients who require emergency hemostasis [7,[27][28][29][30][31][32][33][34]. In a prospective, cohort study that included 43 subjects requiring emergency VKA reversal-26 pending an interventional procedure and 17 experiencing acute bleeding-PCC treatment (Beriplex P/N) resulted in a decrease in INR to 1.3 for the majority (93%) of patients [7].…”