Prothrombin fragment F1 + 2 and thrombin—antithrombin III complex are useful markers of the hypercoagulable state in atrial fibrillation

Asakura, Hitoshi; Hifumi, Senshu; Jokaji, Hiroshi; Saitô, Masanori; Kumabashiri, Ichiro; Uotani, Chika; Morishita, Eriko; Yamazaki, Masahide; Shibata, Kazuaki; Mizuhashi, Keiichi

doi:10.1097/00001721-199203040-00015

Cited by 91 publications

(20 citation statements)

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“…5 Previous studies have demonstrated increased activation of platelets and the coagulation system in the peripheral venous blood in patients with chronic AF (cAF). [6][7][8][9] In patients with paroxysmal AF (pAF), AF itself enhances platelet aggregation and coagulation, and these processes are influenced by the duration of AF. 10 Interestingly, however, ischemic stroke occurs in patients with pAF, even during sinus rhythm.…”

Section: Editorial P 1393mentioning

confidence: 99%

Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation

Motoki

Tomita

Aizawa

et al. 2009

Circ J

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Background: Evaluation of plasma markers of thrombin activity (thrombin-antithrombin III complex: TAT), active fibrinolysis (plasmin-α 2-plasmin inhibitor complex: PIC), and platelet activity (platelet factor 4: PF4) is useful for identifying patients with various cardiovascular disorders who are at high risk of thromboembolism. In this study, these markers were investigated in the left atria (LA) of patients with paroxysmal atrial fibrillation (pAF) in the non-paroxysmal period. Methods and Results: Patients with pAF (n=10) and chronic AF (cAF) (n=10) were enrolled. TAT, PIC, and PF4 levels were determined in blood samples obtained from the LA of AF patients before radiofrequency catheter ablation. TAT levels were high in both pAF and cAF patients. PF4 levels were slightly elevated in both groups, but there was no significant difference between the groups. On the other hand, PIC levels in both groups were almost within normal limits, again with no significant difference between groups. Conclusions: Coagulation activity is elevated in the LA of patients with pAF, even in the non-paroxysmal period, so these patients are at high risk of thromboembolism and anticoagulant therapy is indicated. (Circ J 2009; 73: 1403 -1407

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Section: Editorial P 1393mentioning

confidence: 99%

Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation

Motoki

Tomita

Aizawa

et al. 2009

Circ J

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“…Previously, some studies have evaluated the coagulation system in patients with idiopathic CMP using these hemostatic molecular markers. Asakura et al (13) reported that the plasma levels of thrombin-antithrombin III complex and prothrombin fragment 1+2 were moderately increased in patients with CMP and atrial fibrillation. However, in our study, patients with atrial fibrillation were excluded.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

Açıkgöz

Ermiş²,

Yağmur³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Kardiyomiyopati (KMP) kan stazı, trombosit aktivasyonu ve değişen koagülasyon durumu nedeniyle, artmış tromboemboli ile ilişkili bir hastalıktır. Biz, bu çalışmada iskemik ve idiyopatik KMP'li hastalarda ortalama trombosit hacmini (OTH) belirlemeyi ve onları kontrol grubuyla kıyaslamakla birlikte, KMP'li hastalarda OTH ile ekokardiyografik parametreler arasında bir ilişki olup olmadığını da belirlemeyi amaçladık. Yöntemler: Bu çalışma gözlemsel enine-kesitli çalışma olarak dizayn edildi. Çalışmaya idiyopatik KMP'li 35 hasta, iskemik KMP'li 35 hasta ve kontrol grubu 30 kişi olmak üzere toplam 100 birey dahil edildi. Çalışmaya katılan tüm bireylerin OTH değerleri ölçüldü ve tüm katılanlara transtorasik ekokardiyografi ve anjiyografik değerlendirme yapıldı. İstatistiksel analizler için Ki-kare testi, tek yönlü ANOVA ve Pearson korelasyon testleri kullanıldı. Bulgular: Çalışmamızda OTH değeri idiyopatik ve iskemik KMP'li hastalarda kontrol grubuna göre anlamlı olarak daha yüksek bulundu (9.03±1.3'e karşın 8.77±0.9 ve 7.95±1.0 fl, sırasıyla, p<0.001). Ayrıca OTH değeri idiyopatik KMP'li hastalarda iskemik KMP'li hastalara göre daha yüksekti, ancak bu yükseklik istatistiksel olarak anlamlı değildi (p=0.328). Çalışmamızda OTH değeri ile sol ventrikül diyastol sonu ve sistol sonu çap (r=0.369, p<0.0001; r=0.325, p=0.001, sırasıyla) ve sol atriyal çap (r=0.403, p<0.0001) değerleri arasında pozitif ilişki sol ventrikül ejeksiyon fraksiyonu arasında negatif ilişki bulundu (r=-0.392, p<0.0001). Sonuç: Hem idiyopatik hem iskemik KMP'li hastalarda kontrollerle kıyaslandığında daha yüksek olan OTH değerleri, KMP'li hastaların etiyolojisi ne olursa olsun, trombosit agregasyonuna eğilimini gösterir. Ayrıca, bu hastalarda genişlemiş ve bozulmuş sol ventrikül ile artmış OTH değer-leri arasında bir ilişki olabilir. (Anadolu Kardiyol Derg 2011; 11: 595-9) Anahtar kelimeler: Ortalama trombosit hacmi, tromboz, kardiyomiyopati, ekokardiyografi ABSTRACT Objective: Cardiomyopathy (CMP) is a disorder associated with an increased risk of thromboembolism due to blood stasis, platelet activation and altered coagulation status. In this study, we aimed to investigate mean platelet volume (MPV) in patients with idiopathic CMP and ischemic CMP and to compare with those of the controls, and aimed to determine whether there is a relationship between MVP and echocardiographic parameters in patients with CMP. Methods: This study was designed as an observational cross-sectional study. A total of 100 subjects with idiopathic CMP (n=35), ischemic CMP (n=35) and controls (n=30) were included in the study. The MPV values were measured in all participants. All subjects underwent transthoracic echocardiography and angiographic evaluation. We used Chi-square test, one-way ANOVA and Pearson correlation tests for statistical analysis. Results:The MPV values were significantly higher in patients with idiopathic CMP and ischemic CMP than those of the controls (9.03±1.3 and 8.77±0.9 vs. 7.95±1.0 fl, respectively, p<0.001). The MPV values were although ...

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“…In a study, plasma prothrombin fragment, thrombin, anti-thrombin 3 levels were found to be higher in AF patients with mitral stenosis in comparison with those without MS [20,21]. In a study performed to ascertain the hypothesis of that CV might increase prothrombotic state, Jacob K. et al [22] did not find any difference in any time plasma median D-dimer and protein C levels, however, the authors demonstrated a significant decline in plasma fibrinogen and anti-thrombin 3 levels in early period following CV; this result indicates the formation of thrombin.…”

Section: Sr and Crpmentioning

confidence: 94%

The Effects of Cardioversion on the Prothrombotic Markers and CRP in the Atrial Fibrillation

Demir¹

2012

J Blood Lymph

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Prothrombin fragment F1 + 2 and thrombin—antithrombin III complex are useful markers of the hypercoagulable state in atrial fibrillation

Cited by 91 publications

References 0 publications

Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation

Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation

The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

The Effects of Cardioversion on the Prothrombotic Markers and CRP in the Atrial Fibrillation

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