Prothrombin G20210A Mutation: Is It Associated with Pre-Eclampsia?

Higgins, John R.; Kaiser, Thomas; Moses, Eric K.; North, Robyn A.; Brennecke, Shaun P.

doi:10.1159/000010326

Cited by 34 publications

(11 citation statements)

References 14 publications

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“…[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Our findings in a large white population provide a clear demonstration of the strong association of severe PE with thrombophilia. Diagnosis of PE and assessment of its severity were in strict accordance with the American College of Obstetricians and Gynecologists criteria.…”

Section: Discussionmentioning

confidence: 82%

“…In addition, the limited size of studies of the association of thrombophilia with PE reduces their statistical significance and may result in its overestimation or underestimation. 15,17,23,24,27,31,32 The size of our sample is one of the strengths of our study. Even so, it was insufficient to detect significant differences in the prevalence of inherited deficiency of protein C, protein S, and antithrombin III, all rather infrequent.…”

Section: Discussionmentioning

confidence: 99%

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Thrombophilia Is Significantly Associated With Severe Preeclampsia

Mello

Parretti²,

Marozio³

et al. 2005

Hypertension

143

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Abstract-The role of thrombophilia in the pathogenesis of preeclampsia is controversial. The aim of this case-controlled study was to determine whether thrombophilia increases the risk of preeclampsia or interferes with its clinical course. A total of 808 white patients who developed preeclampsia (cases) and 808 women with previous uneventful pregnancies (controls) matched for age and parity were evaluated for inherited and acquired thrombophilia (factor V Leiden; factor II G20210A; methylenetetrahydrofolate reductase C677T; protein S, protein C, and antithrombin III deficiency; anticardiolipin antibodies; lupus anticoagulant; and hyperhomocysteinemia). Odds ratios (ORs) with 95% confidence intervals (CIs) for risk of being carriers of thrombophilia in cases compared with controls and for risk of maternal life-threatening complications and adverse perinatal outcomes in preeclamptic patients with or without thrombophilia were calculated. Women with severe preeclampsia (406 cases) had a higher risk (OR, 4.9; 95% CI, 3.5 to 6.9) of being carriers of either an inherited or acquired thrombophilic factor, except for protein S, protein C, and antithrombin deficiency. In women with mild preeclampsia (402 cases), only prothrombin and homozygous methylenetetrahydrofolate reductase gene mutations were significantly more prevalent than in the controls. Thrombophilic patients with severe preeclampsia are at increased risk of acute renal failure (OR, 1.8; 95% CI, 1.5 to 2.2), disseminated intravascular coagulation (OR, 2.7; 95% CI, 1.1 to 6.4), abruptio placentae (OR, 2.6; 95% CI, 1.2 to 6.0) and perinatal mortality (OR, 1.7; 95% CI, 1.5 to 2.2) compared with nonthrombophilic preeclamptic patients. Our study demonstrates a significant association between maternal thrombophilia and severe preeclampsia in white women. Thrombophilia also augments the risk of life-threatening maternal complications and adverse perinatal outcomes in preeclamptic patients.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Thrombophilia Is Significantly Associated With Severe Preeclampsia

Mello

Parretti²,

Marozio³

et al. 2005

Hypertension

143

View full text Add to dashboard Cite

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“…Many studies have now been conducted investigating possible associations between PE/E and candidate genes, including angiotensinogen [43,44], methylenetetrahydrofolate reductase [23,45], prothrombin [21], factor V Leiden [46] and others. These studies have failed to reach agreement with one group reporting association of a particular candidate gene with PE/E and another group unable to confirm the association.…”

Section: Discussionmentioning

confidence: 99%

Association of the TNF2 Allele with Eclampsia

Kaiser

Grehan

Brennecke

et al. 2004

Gynecol Obstet Invest

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The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α –307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α –307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ² = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ² = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

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“…No difference in homozygosity for MTHFR was found between the 2 groups (preeclampsia 3% vs controls 6%). Higgins et al [62], tested the prothrombin mutation in 13 eclamptic and 74 preeclamptic women with severe disease coming from 34 families of mostly Anglo-Saxon origin. They were compared to 119 controls.…”

Section: Inherited Thrombophilias and Pregnancy Complications Severe mentioning

confidence: 99%

Thrombophilia and pregnancy

Kupferminc

2003

Reprod Biol Endocrinol

139

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Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage and has also been associated with thrombophilia. Finally, thromboembolism in pregnancy as in the non-pregnant state is linked to thrombophilia. In this review all aspects of thrombophilia in pregnancy are discussed, and also all prophylactic and therapeutic implications.

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Prothrombin G20210A Mutation: Is It Associated with Pre-Eclampsia?

Cited by 34 publications

References 14 publications

Thrombophilia Is Significantly Associated With Severe Preeclampsia

Thrombophilia Is Significantly Associated With Severe Preeclampsia

Association of the TNF2 Allele with Eclampsia

Thrombophilia and pregnancy

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