Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein

Dennis, Michael; Downey, Colin; Brufatto, Nicole; Nesheim, Michael E.; Stevenson, Ken; Toh, Cheng Hock

doi:10.1160/th03-08-0548

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…The very low density lipoprotein components from patients with BPW have been found to increase prothrombinase activity (29). The BPW is a transient phenomenon, lasting 2-3 days and preceding the diagnosis of overt disseminated intravascular coagulation by Table 3.…”

Section: Discussionmentioning

confidence: 99%

Activated partial thromboplastin time waveform analysis: A new tool to detect infection?*

Chopin

Floccard

Sobas

et al. 2006

Critical Care Medicine

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Section: Discussionmentioning

confidence: 99%

Activated partial thromboplastin time waveform analysis: A new tool to detect infection?*

Chopin

Floccard

Sobas

et al. 2006

Critical Care Medicine

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“…We have shown here that the CRP was increased in the patients with high DIC scores. CRP was highly elevated in the DIC patients having a biphasic transmittance waveform, and thrombin generation could be promoted by the CRP-very low density lipoprotein complex [14]. Even though the CRP level alone does not predict DIC, the CRP level, which was correlated with DIC score, may have a physiological role in the active thrombin generation of DIC.…”

Section: Discussionmentioning

confidence: 99%

Utility of the Fibrinogen/C-Reactive Protein Ratio for the Diagnosis of Disseminated Intravascular Coagulation

Kim

Lee²,

Kang³

et al. 2006

Acta Haematol

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Although the presence of decreased plasma fibrinogen has been regarded as an indicator of ongoing disseminated intravascular coagulation (DIC), fibrinogen, which is one of the acute phase reactants, is often increased in the patients with DIC. We investigated the diagnostic and prognostic utility of a new parameter [the fibrinogen/C-reactive protein (CRP) ratio] for predicting DIC in 1,056 patients with suspected DIC and who also had underlying disorders associated with DIC. Among the 535 patients with overt DIC, 46 patients (8.6%) showed low plasma fibrinogen (<100 mg/dl), suggesting that the plasma fibrinogen level is not a sensitive marker for DIC. There was a strong correlation between the increased DIC scores and increased number of patients with low (<104) fibrinogen/CRP ratios. Among the three groups with different serum fibrinogen/fibrin degradation product levels, the fibrinogen/CRP ratio showed a higher difference than did the fibrinogen level. The DIC score was highly correlated with the 28-day mortality and the number of patients with low fibrinogen/CRP ratios. The odds ratio (the relative risk of 28-day mortality) of the low fibrinogen/CRP ratio was 6.15, while the odds ratio of the low fibrinogen level was 2.13. The area under the receiver-operating characteristic curve of the fibrinogen/CRP ratio, when this was used for predicting mortality, showed significantly better discriminative power than did that of the fibrinogen level. This study demonstrates that the fibrinogen/CRP ratio may provide more discriminating power for identifying the patients with active coagulation consumption, and the fibrinogen/CRP ratio has a good predictive value concerning the 28-day mortality in the patients suspected of having DIC. The results of our study suggest that replacement of fibrinogen by the fibrinogen/CRP ratio for calculating the DIC score may lead to enhance diagnostic and prognostic power for DIC.

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“…ANXA5 is a member of the annexin family of calcium-dependent phospholipid-binding proteins (10). In addition, a previous study by Dennis et al (11) reported that ANXA5 may affect triglyceride metabolism. These results suggested that an association between ANXA5 and lipid metabolism may be an important aspect of obesity.…”

Section: Introductionmentioning

confidence: 95%

Association of annexin A5 polymorphisms with obesity

et al. 2013

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Abstract. Annexin A5 (ANXA5), which is known as a protein with anticoagulative function, may play a role in triglyceride biosynthesis. Triglycerides are involved in lipid and energy metabolism, which are important in the elucidation of obesity. To investigate the association between single-nucleotide polymorphisms (SNPs) of ANXA5 and obesity in a Korean population, 372 participants (213 overweight/obese individuals and 159 control subjects) were enrolled from the Kyung Hee University Medical Center and Keimyung University Dongsan Medical Center. The genotypes of five SNPs (rs12510548, rs4240260, rs3756281, rs13136094 and rs6534313) were evaluated in ANXA5 using the multiple logistic regression analysis with the codominant 1, codominant 2, dominant, recessive and log-additive models. The genotype and allele frequencies of the five investigated SNPs exhibited significant differences between the control and the overweight/obese groups: rs12510548 (P=0.004 in the codominant 2 model, P=0.0019 in the recessive model, P=0.027 in the log-additive model and P=0.026 in allele frequencies); rs4240260 (P=0.002 and Fisher's exact P=0.0006 in the codominant 2 model, P=0.0007 and Fisher's exact P=0.0007 in the recessive model, P=0.020 and Fisher's exact P=0.0019 in the log-additive model and P=0.020 in allele frequencies); rs3756281 (P=0.016 in the codominant 2 model and P=0.0094 in the recessive model); rs13136094 (P=0.0030 and Fisher's exact P=0.0011 in the codominant 2 model, P=0.0012 and Fisher's exact P=0.0013 in the recessive model, P=0.034 and Fisher's exact P=0.0035 in the log-additive model and P=0.024 in allele frequencies); and rs6534313 (P=0.0010 and Fisher's exact P=0.0003 in the codominant 2 model, P=0.0003 and Fisher's exact P=0.0003 in the recessive model, P=0.0075 and Fisher's exact P=0.0010 in the log-additive model and P=0.005 in allele frequencies). Two haplotypes were weakly associated with obesity (GGATG, P=0.037 and CAGCC, P=0.020). Results of the present study suggested that ANXA5 may be associated with the development of obesity in a Korean population.

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Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein

Cited by 22 publications

References 26 publications

Activated partial thromboplastin time waveform analysis: A new tool to detect infection?*

Activated partial thromboplastin time waveform analysis: A new tool to detect infection?*

Utility of the Fibrinogen/C-Reactive Protein Ratio for the Diagnosis of Disseminated Intravascular Coagulation

Association of annexin A5 polymorphisms with obesity

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