2006
DOI: 10.1007/s10565-006-0082-4
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Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism

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Cited by 121 publications
(74 citation statements)
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“…4). Studies using cell and animal models show the effects of phenolic acids on both the expression and activity of enzymes involved in the production of inflammatory mediators (53)(54)(55)(56)(57)(58)(59)(60)(61)(62) . For example, COX-2 expression and activity are reduced by p-coumaric acid in dextran/sodium sulphate (DSS)-induced inflammation in a rodent model (57) and caffeic acid suppresses the expression of IL-17 and ameliorates DSS-induced colitis in mice (56) .…”
Section: Potential Biological Activity Of Phenolic Acidsmentioning
confidence: 99%
“…4). Studies using cell and animal models show the effects of phenolic acids on both the expression and activity of enzymes involved in the production of inflammatory mediators (53)(54)(55)(56)(57)(58)(59)(60)(61)(62) . For example, COX-2 expression and activity are reduced by p-coumaric acid in dextran/sodium sulphate (DSS)-induced inflammation in a rodent model (57) and caffeic acid suppresses the expression of IL-17 and ameliorates DSS-induced colitis in mice (56) .…”
Section: Potential Biological Activity Of Phenolic Acidsmentioning
confidence: 99%
“…The Martin-Perez group demonstrated that this was due in part to activation of mitogen-activated protein kinases (MAPK) by lauryl gallate (2c) and, more particularly, the ERK1/2 kinases (Table 1) [29]. Protocatechuic acid (3) was capable of stimulating c-Jun N-terminal kinase (JNK), another p38 MAPK, and as a consequence induced cell death in HepG2 hepatocellular carcinoma and AGS human gastric adenocarcinoma cells (Table 1) [30,31]. Caffeic and ferulic derivatives (5, 6 and 7) target specifically the PKC protein kinase family and arrest growth of various cancer cells, such as for example U937 human leukemic cells (Table 1) [18,32,33].…”
Section: Group I: Polyphenolic Acids and Their Analoguesmentioning
confidence: 99%
“…Epidemiological studies have shown relationships between consumption of polyphenol-rich foods and prevention of diseases, such as coronary heart disease and osteoporosis [13]. Research showed that CGA has bacteriostatic, hypoglycemic, anticancer, anti-inflammatory, and antiviral activities [3,[14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%